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'In this Review, we present current knowledge on the role of MDSCs in the immunotherapy of melanoma. We describe the accumulation, infiltration, and immunosuppressive functions of MDSCs in the tumor microenvironment (TME) as well as existing therapeutic strategies to target them in melanoma-bearing hosts. A special focus is placed on preclinical studies and clinical trials applying MDSC inhibition to overcome resistance to ICIs.'

jci.org/articles/view/170762

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