"Another key parameter in CAR T cell infusion products is the ratio of CD4:CD8 T cell subsets. Yet, it is unclear whether CD4+ and CD8+ CAR T cells have the same propensity to induce CRS. This is particularly relevant since CD4:CD8 ratios can vary extensively in distinct infusion products."

#Immunology #immunotherapy #CARTCells

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00314-2