'Because a certain domain is present in a protein, you shouldn’t assume that it has a certain function, and IDRs (famously or notoriously) have suffered from this in the past several years. We see many papers where the authors assume that the presence of an IDR means that a protein might undergo phase separation or that they are readily interchangeable. Current work is challenging these assumptions, showing many examples where IDRs are not interchangeable, and revealing many cases where phase separation is not biologically relevant.'

https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00178-3