"Plenge and colleagues are laying out a three-part plan to tackle autoimmune diseases of all types. Under this vision, ‘step one’ drugs — including many available small molecules and antibodies — would be used to control the inflammation that marks these disease. ‘Step two’ drugs, exemplified by CAR Ts, could be used to reset the immune system by taking out the pathogenic immune cells that drive the inflammation. And ‘step three’ drugs could promote homeostasis and the repair of any lasting damage."
#Immunology #Autoimmunity #AutoimmuneDisease #Immunotherapy #CARTcells
https://www.nature.com/articles/d41573-024-00069-5