'Determining how 11,269 enzyme structures catalysing 361 different metabolic reactions evolved over 400 million years alongside their molecular functions, we report that metabolism has shaped the structural evolution of enzymes at different levels: the organisms overall metabolism; the topological organisation of the metabolic network; and each enzymes molecular properties.'
#Preprint #Evolution #StructuralBiology #AlphaFold
https://www.biorxiv.org/content/10.1101/2024.05.27.596037v1