Host immunity in phage therapy:
"Bacteriophage immune neutralization was observed between 6 and 35 days after initiation of BT in 5 of 13 (38.5%) screened patients (9, 13, 20, 66 and 92 in Table 2 and Fig. 4a–d). Bacteriophage immune neutralization always involved invasive (intravenous and/or intralesional) bacteriophage administrations. In 4 of these 5 cases (patients 9, 13, 20 and 92), clinical improvement and eradication of the targeted bacterial pathogen were nevertheless observed."
Fm Pirnay et al, Nat Microbiology 2024.
#Immunology #Phage #AntibioticResistance
https://www.nature.com/articles/s41564-024-01705-x?utm_campaign=related_content&utm_source=HEALTH&utm_medium=communities#Sec11