"Here, we provide evidence for a new metabolic mechanism of ECM regulation driven by the upload of CAF-secreted lactate. Lactate-induced α-KG is exploited by P4H collagen prolyl-hydroxylase, impacting on collagen deposition. Moreover, we identified a type I collagen/DDR1/STAT3 axis as a signaling node required to promote a collagen-dependent achievement of pro-metastatic features in stromal lactate-reprogrammed PCa cells."
Ippolito et al @emboreports
https://www.embopress.org/doi/full/10.1038/s44319-024-00180-z