'MALAT1 is a highly abundant long non-coding RNA (lncRNA) that is retained in the nucleus (Sun and Ma 2019). It is consistently highly expressed across mammalian species, and its function is related to splicing regulation, the cell cycle, or the structure of the nuclear speckle (Hutchinson et al. 2007; Sun and Ma 2019). We found that MALAT1 expression is highly correlated with the DropletQC nuclear fraction measure and thus can be used to identify poor quality cells from scRNA-seq datasets. MALAT1 expression is an important technical signal that easily and quickly indicates the presence of a nucleus in droplets in scRNA-seq data.'
https://www.biorxiv.org/content/10.1101/2024.07.14.603469v1