Metformin + anti-PD1

"We found that the combination therapy promotes the pericyte coverage of tumor vascular endothelial cells (ECs) to improve blood perfusion and that it suppresses the hyperpermeability through the increase of VE-cadherin. Peripheral node addressin(PNAd) and vascular cell adhesion molecule (VCAM)-1"
#Immunology #Immunotherapy
https://www.pnas.org/doi/10.1073/pnas.2404778121