Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'An important aspect of this study is that we inferred the fitness landscape based on antibiotic resistance profiles and not genotypes. Although previous studies have focused on constructing fitness landscapes based on mutations for a few genes [4,6], because the number of possible genotype changes (e.g., nucleotide changes) associated with antibiotic resistance evolution is immense [32], empirical fitness landscapes based on genotypes were not capable of predicting/controlling evolution.'
#Evolution #EvolutionaryBiology #antibioticresistance #FitnessLandscape @PLOSBiology
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001920#sec008
Madalena has been on a #ceramics rampage for a few months now.
Here's a cephalopod for the New Year.
More at the link below
A bit outside what we normally get, but a very nice white from Pico, in the Azores.
You can add Lisbon to this 'unlike' list.
"But the thing that really surprised me when I moved here was how reasonable the rents are compared with London, New York and most other European capitals. The reason for this is Vienna City Council’s radical social housing policy. It is the largest property owner in Europe. Some 60 per cent of the population live in high-quality subsidised housing, including middle-class families and young professionals. Unlike London, nurses, teachers and public servants can afford to live in the centre."
https://www.ft.com/content/05719602-89c6-4bbc-9bbe-5842fd0c3693
This is why Count Rugen was so demanding
“Yet in one key respect, Kennan’s diaries proved unrevealing. Like many people, Kennan journaled less when he was busy, and there is virtually nothing of consequence from 1946 or 1947, when he wrote the two documents on which his influence rested and when he began to reconsider fundamental assumptions about the nature of the Soviet challenge and the preferred American response. For the entirety of 1947, arguably the pivotal year of both the early Cold War and Kennan’s career, there is but a single entry: a one-page rhyme.”
https://www.foreignaffairs.com/reviews/ghosts-george-kennan-lessons-cold-war
From a small producer in Dao (a very underrated region of Portugal), a red
#WinesOfMastodon
cc @BLMG
"There is literally never a dull shot. And he found in Toshiro Mifune, star of Rashomon and 15 other films in the Kurosawa canon, an antic presence with acting strokes to match. Mifune’s performance is as vivid as a Japanese ideogram. (Note for Kurosawa biographical completists: he studied calligraphy and kendo swordplay as a child.)"
https://www.ft.com/content/29b63a0f-3c30-4de9-9456-fa48118978ff
Votive ears (Egypt, 1539-1069 BCE) for speaking directly to the gods at the Gulbenkian Museum
'The mutant flowers were UV reflective as expected but additionally contained low levels of visible anthocyanin pigments. Hawkmoths strongly preferred the wild-type P. axillaris over the myb-fl mutant, whereas both social and solitary bee preference depended on the level of visible color of the mutants.'
#CurrentBiology #Pollination #Evolution @CurrentBiology
https://www.cell.com/current-biology/fulltext/S0960-9822(22)01762-6
"Conditional absence of C3aR1/C5aR1 on neutrophils lowered serum BAFF levels, led to fewer Peyer’s patch germinal center B cells, reduced germinal center B cells IgA class-switching, and lowered fecal IgA levels. Together, the results indicate that sequential activation of complement on neutrophils crucially supports humoral TI and mucosal IgA responses through upregulating neutrophil production of BAFF."
The latest episode of the EMBO Podcast #EMBOPodcast is out 🎧
I spoke with Roger Reddel & Tracy Bryan at Sydney's Children's Medical Research Institute about their classic 1995 @embojournal paper describing #telomerase independent #telomere lengthening in immortalised cell lines. It challenged conventional wisdom at the time - and it was Bryan's PhD project, quite a way to get started in science.
@miguelgf provided some perspective on the work and its enduring significance and editor @HVodermaier explained #EMBOJournal's interest in studies with striking findings that may not provide a full mechanistic description.
You can listen to "ALTernative immortality" at the link below or on your preferred podcast app. Special thanks to Igor Jukic & audio producer extraordinaire @marcoantonio
"Zombie fly. A parasitic fungus erupts from the body of a fly in the Tambopata National Reserve in Peru. Evolutionary biologist Roberto García Roa captured the shot, which won this year’s BMC Ecology and Evolution image competition. The spores of the ‘zombie’ fungus infiltrate the fly’s exoskeleton and brain and compel it to migrate to a location that is more favourable for the fungus’s growth.
Credit: Roberto García-Roa (CC BY 4.0)"
https://www.nature.com/immersive/d41586-022-04372-2/index.html
'In recent years, the vast archaeological park of Pompeii, a city buried alive by the eruption of Vesuvius in A.D. 79, has turned to high-tech options to maintain its excavated ruins. A surveillance drone makes a monthly flight over the site’s roughly 10,000 exhumed rooms. Artificial intelligence programs analyze aerial images for new cracks, fallen stones and other signs of erosion. But to prevent the third of the park that remains hidden under pumice and meters of earth from becoming overgrown with thorn bushes, wild hedges and trees, Pompeii has found a more appropriately ancient, and inexpensive, solution in hungry sheep.'
https://www.nytimes.com/2022/12/22/world/europe/pompeii-sheep-mount-vesuvius.html
"Here, we tracked the co-development of microbiomes and metabolomes from late pregnancy to 1 year of age using longitudinal multi-omics data from a cohort of 70 mother-infant dyads. We discovered large-scale mother-to-infant interspecies transfer of mobile genetic elements, frequently involving genes associated with diet-related adaptations"
cc @Odedrechavi (even though it's not in worms, it might still be interesting)
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
