Thiago Carvalho @cyrilpedia@qoto.org

'Here, we bridge the gap between meta-analysis methodology and open science principles by proposing quick tips for open, transparent meta-analyses. These tips, summarized in Fig 1, are intended to help researchers design, conduct, and publish meta-analyses that adhere to the highest standards of openness and transparency, ensuring that their findings can be trusted, replicated, and built upon by the scientific community. We also provide a checklist to help researchers, reviewers, and journal editors implement these guidelines in practice'

https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012252

To paraphrase Hansel, the nero is *in* the seppia.

"Sweet Smell of Success is a true classic. The passing of half a century has deepened its manifold pleasures. We do not mind the absence of a few genre conventions, like a hero or hope or justice, when we can get, in spades, scintillating dialogue, ingenious photography, keyed-up performances, and coolly thumping music, all paced at a carousing canter."

https://www.criterion.com/current/posts/1761-sweet-smell-of-success-the-fantastic-falco

Havent read this one yet, but Ogawa's "Memory Police" is fantastic, if you're looking for a book to enjoy in the closing days of August (it's not long).

https://lithub.com/the-10-best-book-covers-of-august/

"Cameron created a pantheon of hairy brainboxes, boasting that ‘the greatest men of the age (...) Joseph Hooker, one of her most keenly defined portraits, looks as if he is trying to escape his whiskers."

https://www.lrb.co.uk/the-paper/v46/n16/susannah-clapp/on-julia-margaret-cameron

Recycling the leftovers.

From Chistopher Sexton's biography of Macfarlane Burnet, "The Seeds of Time".

#Immunology

In which Madalena fills the oven

#Arts #Ceramics #Pottery

https://madalenaparreira.com

From Masha Gessen's 2012 book, The Man Without a Face: The Unlikely Rise of Vladimir Putin (highly recommended)

'She’s the one whose performances offer the most surprises, the most shocks, the most moment-to-moment inventiveness, and, above all, the most almost-unbearable force of emotional expression, combining extremes of strength and vulnerability, of overt display and inner life.'

https://www.newyorker.com/culture/the-front-row/how-gena-rowlands-redefined-the-art-of-movie-acting

Alain Delon 1935-2024

Physics envy, 1956

(from Dan Davis' "The Beautiful Cure).

"How your email finds me"

Somewhere in the Serra da Estrela

"This review discusses state-of-the-art techniques for the simultaneous profiling of multiple chromatin features in low-input samples and single cells, focusing on histone PTMs, DNA-binding, and chromatin proteins."

https://www.embopress.org/doi/full/10.1038/s44319-024-00199-2

'LINE1 (L1) retrotransposons have gained notoriety for their involvement in a slew of pathologies. While improper de-repression of L1 transcription may drive disease, mammalian cells have coopted L1 activation into mechanisms essential for cell function. New findings published by Mangiavacci et al (2024) in The EMBO Journal reveal the role of L1 RNA in stimulating osteogenic activity during bone repair in both mice and humans, highlighting a previously undescribed beneficial regulatory role for L1 activity.'

https://www.embopress.org/doi/full/10.1038/s44318-024-00175-5

If you're thinking "hey, what I need right now is more dystopia", this is the novel for you.

Tools
"To address these issues, we present a scalable and reproducible pipeline for Proximity Labeling-based proteomics (Fig. 1), incorporating automated enrichment of biotinylated proteins in a 96-well plate format and an optimized proteomics method for reproducible protein quantification."
#Proteomics
https://www.embopress.org/doi/full/10.1038/s44320-024-00049-2

Gratuitous cork shot

I picked this one up by chance at a bookstore in Kyoto, Kobo Abe's The Ark Sakura. It opens with a grifter selling.. fake insects & flows into a story of a DIY dystopia, prominently featuring a toilet.

Recommended.