Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
“I trust you will not allow yourself to be in any way disgusted or annoyed by the considerable abuse and misrepresentation which, unless I am greatly mistaken, is in store for you,” Huxley had written Darwin just before the publication of “The Origin.” “I am sharpening up my claws and beak in readiness.”
https://www.newyorker.com/magazine/2022/11/28/how-the-huxleys-electrified-evolution
'Exposição Dinossauros — O Regresso dos Gigantes estará em Lisboa até Setembro de 2023. É uma visita ao maravilhoso mundo dos dinossauros, onde até se pode ser paleontólogo.'
'An abstractionist before the official advent of abstraction, Hilma af Klint was a member of an all-female group called the Five from 1896 to 1907, participating in meditation and séances to channel the messages of mystics. In the studio, she harnessed this spiritual practice into unorthodox, nonfigurative paintings.'
'In a cleverly designed experiment, Galvez-Pol et al. used electrocardiography to record the cardiac activity of participants while they performed a simple tactile discrimination task. Without looking, the participants had to figure out whether the objects they touched had vertical or horizontal grooves. They found that touches initiated during systole were held for longer than touches initiated during diastole'
I like this intro jump from Mitchison to Sakaguchi (ref 21 to 22)
"Forty years ago, high-zone immune tolerance had been suggested to be mediated by suppressor T cells (21). The existence of suppressor T cells has long remained controversial and was not accepted until regulatory T cells (Tregs) were characterized more than 15 years later (22)."
On Ralph Ellison, photographer.
"Judging the photographs of an artist who is not primarily a photographer raises a prickly question. Are you assessing the photos on their own merits or examining them to better understand the artist’s main work? With an artist like Degas, his photos can be regarded as preparatory sketches for paintings. But what happens when the artist is not a painter but a writer?"
'By the time attorney George Templeton Strong diagnosed his own bibliomania in 1842, the book madness had gripped New York. “Bibliomania is a kind of constitutional disease with me,” he confessed to his diary. “I’ve been subject to it almost as long as I can remember.”'
With the holidays approaching, keep in mind that nothing says "I'm sorry" like the gift of a sacrificial spider monkey.
Nice cover illustration by Felipe Serrano (www.illustrative-science.com) For Cabral-Miranda et al's "Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging" in the #EMBOJournal
'At the time, Argentina’s regime, the bloodiest in modern South American history, was rounding up thousands of real and presumed leftists and putting them in torture camps or killing them outright in what came to called the “dirty war.” The dictatorship lasted seven years, during which at least 8,960 people disappeared, according to official estimates. Some human rights groups put the figure at 30,000.'
"Here, we have identified the mTOR pathway as a major determinant of chemosensitivity through a genome-wide CRISPR knockout screen. We show that mTOR inhibition causally leads to the emergence of a reversible drug-tolerant persister population with a senescence phenotype, which is dependent on autophagy and G2/M cell cycle arrest for survival."
'Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest major cancers, contrasting a relatively low incidence rate1. The primary reasons for this are related to the difficulty with early detection and a lack of effective therapeutic options. A principal barrier to treatment of pancreatic cancer is the densely fibrotic tumor microenvironment, the high interstitial pressure of which acts to collapse blood vessels and impair the delivery of chemotherapy. This lack of functional vasculature leads to deregulated nutrient availability within the tumor, causing cancer cells to develop numerous metabolic adaptations to allow for proliferation under hypoxic and austere conditions'
While carbonidiots of PS & PSD fervently debate new airport locations, I can't get to Madrid by train from Lisbon.
Let's hope this is for real
"Todo ello ocurre, sin embargo, en un momento en el que las líneas ferroviarias entre Madrid y Lisboa siguen atascadas: no existe un tren directo desde que se suspendió hace tres años, algo que solo había ocurrido durante la guerra."
https://elpais.com/opinion/2022-11-23/la-distancia-de-portugal.html
40 years of Love & Rockets
"There were Chicana punk rockers and Southern California skinheads; entire panels of untranslated Spanish; horn-headed gajillionaires and female ex-gang members; and a dialogue-free, noirish fever dream about writer’s block. There were dozens of characters who looked a lot like the people the brothers grew up around, eating, sleeping, laughing, partying, and grousing about work. Much of “Rockets” was set in Huerta, nicknamed Hoppers, a majority Latino town not unlike Oxnard."
https://www.nytimes.com/2022/11/19/books/love-and-rockets-hernandez-bros.html
"This weary skepticism for the scientific endeavor rings through many of Vonnegut’s 14 novels and dozens of short stories. For what would have been the famed author’s 100th birthday, Science talked to literary scholars, philosophers of science, and political theorists about the messages Vonnegut left for the scientific community—and why he’s more relevant than ever."
"Activity tracing by plasma proteomic profiling uncovered an association between low NET clearance and increased COVID-19 pathology and mortality. Low NET clearance activity with comparable proteome associations was prevalent in healthy donors with low-grade inflammation, implicating defective chromatin clearance in the development of cardiovascular disease and linking COVID-19 susceptibility to pre-existing conditions"
#Immunity #Immunology
#Neutrophil #COVID19 #Pathology
https://www.cell.com/immunity/fulltext/S1074-7613(22)00597-0
"Arqueólogos hallan dos gavilanes vestidos con ornamentos de turquesa y oro, vinculados con Huitzilopochtli, dios de la guerra.
ANTONIO MARÍN CALVO/ PROYECTO TEMPLO MAYOR"
https://elpais.com/mexico/2022-11-21/la-ultima-ofrenda-hallada-en-el-templo-mayor-aves-de-oro-sobre-cuchillos-de-pedernal-serpientes-y-espinas-de-maguey.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
