Thiago Carvalho @cyrilpedia@qoto.org

Sagy et al. have recently published in #NatureMedicine an analysis of the real-world efficacy of #JYNNEOS, the #smallpox shot redeployed against #monkeypox.
https://www.nature.com/articles/s41591-023-02229-3

Last Fall I wrote a column for Nature Medicine that touched on the FDA's Animal Rule, used in the approval of anti-smallpox drugs due to the difficulty in designing ethically acceptable efficacy screens.

https://www.nature.com/articles/d41591-022-00094-0

"The IBRO Parenthood Grant aims to support early-career Principal Investigators who are approaching parental leave (either via birth or adoption) by providing supplemental laboratory funding."

https://ibro.org/parenthood-grants/

"Among the things Florida objected to: the course’s discussions on reparations, queer studies, feminist thought and intersectionality – referring to the way various systems of oppression are interconnected."

https://www.theguardian.com/education/2023/feb/13/ap-african-american-studies-florida-ron-desantis

"I always think about climate justice as multitasking. We live in a time of multiple overlapping crises: we have a health emergency; we have a housing emergency; we have an inequality emergency; we have a racial injustice emergency; and we have a climate emergency, so we’re not going to get anywhere if we try to address them one at a time. We need responses that are truly intersectional. So how about as we decarbonise and create a less polluted world, we also build a much fairer society on multiple fronts?"

https://www.theguardian.com/books/2023/feb/13/its-inequality-that-kills-naomi-klein-on-the-future-of-climate-justice

'Two weeks after the last dose, antibodies to P. falciparum circumsporozoite protein and PfSPZ were higher in protected versus unprotected vaccinees. A three-dose regimen of PfSPZ Vaccine demonstrated safety and efficacy against malaria infection in malaria-experienced adults.'

#Immunology #Malaria #InfetionImmunity #vaccine
https://www.science.org/doi/full/10.1126/scitranslmed.abj3776?af=R

@BLMG A foto e' antiga, aviso quando for hora do update!

'Molecular glue degraders are defined as the compounds leading targeted protein degradation (TPD) by creating novel ligase-substrate interactions. Here, we identified AK59 as a novel molecular glue degrader for STING.'

#Preprint #Immunology

https://www.biorxiv.org/content/10.1101/2023.02.08.527642v1?fbclid=IwAR0WPfDyebknVo9PiPLh54GcWR1M479oiFECuex81gmYLiFBMzpBZY8Vhvg

Bairrada.

'Determined to catch up, Japan is ramping up a 1.1 trillion yen ($8.5 billion) initiative that aims to give Japan the capability to develop a vaccine for a new virus in 100 days, a goal being adopted by many countries.'

https://www.science.org/content/article/japan-moves-bolster-vaccine-r-d-after-covid-19-exposed-startling-weakness#.Y-jG3IgQ2Ug.linkedin

Public health in 21st century America.

"Mississippi’s woes are an acute example of a larger public health failure that is reprised nearly every time a major health threat grabs headlines. The problem, experts say, is that Congress starves state and local health agencies of cash for even basic needs in quiet times."

https://www.nytimes.com/2023/02/13/us/politics/covid-public-health-departments.html

"We children of the Boomers went into the workplace with a double expectation – we wanted a proper occupation, and we wanted it to be a vocation. And once again, science seemed to fit the bill."
@TIR_scienceblog

https://totalinternalreflectionblog.com/2023/02/12/science-vocation-to-professionto-job/

For the "every cell is an immune cell" files:

'In this Essay, we present fibroblasts as not only the builders and renovators of tissue environments but also the rheostat cells for immune circuits. Although they perform location-specific functions, they do not have badges of fixed identity'

#Immunology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001954