Thiago Carvalho @cyrilpedia@qoto.org

"It is often assumed that generic drugs are affordable and widely available to those who need them. But this is not entirely true. For example, even after patent expiries open the door to generic rivals, low levels of competition between companies in smaller markets means that generics can actually be more expensive in poor countries than in wealthy ones."

https://www.ft.com/content/99d64932-fd04-488f-9c63-b3646083cbbc

@cyrus You can get a lot done on a manilla A3

'Marty once said of Dave, “I was lucky to get him. We taught him how to grow Tetrahymena, and he taught us a lot about how to do science.”'

https://www.cell.com/cell/fulltext/S0092-8674(23)00089-2

'I remember, many years ago, sitting mystified through a seminar where the leading lights of English philosophy gathered in Oxford to discuss John Rawls’s newly published Theory of Justice. There was radical disagreement as to what Rawls meant to say. The answer seemed to me (a young Skinnerian) obvious: why not phone him up and ask him?'

https://thecritic.co.uk/issues/february-2023/the-enlightenment-as-reading-project/

Print by Madalena Parreira & Constança Arouca

“Map 10 The Turbulence Chart (Lviv, Ukraine, circa 1890)

This engraving was part of a set that illustrated the fabled, never published, “Order & Disorder” manuscript by Bronislaw Zamoyski (sometimes referred to as the “Leibniz of Lviv”). The text and all accompanying illustrations were thought to have been lost when the Russian Army captured Lviv in 1914. How it was obtained by von Willebrand remains unknown.”

https://madalenaparreira.com/SPAM

The NIH is requesting input on postdoc career structure and funding (Closing date in April 14th).

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-23-084.html

Well played

"Despite the multifactorial pathogenesis, available data show that long COVID is an organic post-acute infection syndrome (PAIS) with clear physiological dysfunction that is often not consistently apparent using standard medical diagnostic tests."

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00053-1/fulltext?s=09

"Recognizing that more is better is now an invalid assumption,1 the 2023 US Senate appropriations bill for FDA (included in S. 4661) and its report language encourage FDA to organize dose optimization clinical trials of marketed anticancer agents in an effort to reduce waste and/or toxicities of treatment without compromising efficacy."

https://ascopubs.org/doi/full/10.1200/JCO.22.02049?role=tab

'In the following review, we perform a synthesis of the different types of tumor antigens now being targeted with TCR-T cell therapy in the clinic and new promising antigens developed at the preclinical stage.'

#immunology #immunotherapy

https://www.science.org/doi/10.1126/sciadv.adf3700#.Y-1cGIGJPoE.linkedin