Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Our Andrea Sottoriva (Head of HT Computational Biology Research Centre) and colleagues from #ICRLondon analyzed >10k tumors and 356 metastases to develop a computer algorithm that identifies the probability of a patient's response to #cancer immunotherapy.
Published in @Nature@mstdn.social @naturegenet
@nature@sciencemastodon.com
#tumors #lifesciences #science #sciencemastodon #humantechnopole #datascience #computationalbiology #biology #ai
Thiago Carvalho
boosted
#PlantScience research summaries!
https://plantae.org/plant-science-research-weekly-march-10-2023/
Salt-tolerant crops, time to deliver;
Blushing hungry plants;
Burning lignin, cues for smoke signals;
Temperature sensing in plants;
Role of H2A.Z in thermomorphogenesis;
H3.3(K27A) ->over-lignification in Arabidopsis;
EIN/EIL1 affect FLC via histone demethylase;
siRNAs -> YUP -> pigmentation in Mimulus;
Warm-adapted species in soil seed banks;
Bioengineered “pikobodies” confer plant disease resistance.
Mental health RFI at the NIH
https://grants.nih.gov/grants/guide/notice-files/NOT-MH-23-175.html
This is pretty cool:
'Here, we link PIEZO-mediated mechanotransduction to NLRP3 inflammasome activation. Yoda1, a PIEZO1 agonist, dramatically lowers the threshold for NLRP3 inflammasome activation. PIEZO-mediated stiffness-sensing increases NLRP3-dependent inflammatory responses. Activation of PIEZO1 triggers calcium influx, which activates KCNN4, a calcium-activated potassium channel, to evoke potassium efflux promoting NLRP3 inflammasome activation.'
Meanwhile, at Radiolab
“We’re like a rat king, but a nice rat king,” Nasser volunteered. “Our tails have been tied together through fate and circumstance and we all have to scurry in the same direction.”
https://www.nytimes.com/2023/03/07/arts/radiolab-new-hosts-lulu-miller-latif-nasser.html
Thiago Carvalho
boosted
Origin stories:
"I asked (Bert Vogelstein & Ken Kinzler), 'What prompted you to hire a naive undergraduate from Australia?'
I'd put on my CV 'hobbies: bushwalking', which is hiking in Australian.
They said that they were so intrigued by someone who bushwalked that they needed to meet me."
Tracy Bryan, co-discoverer of ALT, a classic @embojournal paper, on the #EMBOPodcast
"Ópera de Manaos (Brasil). ¿Un aria de Verdi en el corazón de la selva? Pues sí. Manaos es la ciudad más grande del Amazonas, un incongruente reducto de urbanización en medio de la jungla. Su famoso teatro de la ópera se inauguró en 1986, en pleno auge del caucho en la región, y simboliza la opulencia que en su día tuvo esta urbe brasileña. Los artesanos y la mayor parte de los materiales utilizados (mármol y vidrio italianos y hierro escocés) llegaron de Europa; la madera es brasileña, pero se talló en Portugal. La carretera de la entrada se hizo de goma para silenciar los vehículos que llegaran tarde a la función. El Festival de la Ópera del Amazonas dura tres semanas entre abril y mayo y lleva el 'bel canto' a las profundidades de la Amazonia."
Thiago Carvalho
boosted
This was an interesting read: how can lab members contribute positively to the lab environment?
Tenure track positions open at FMI (Basel)
https://www.fmi.ch/education-careers/positions/jobdetails.html?jobID=289
'Since the beginning of 2022, more than 50 million poultry birds in the United States, and a similar number in Europe, have either died of the disease or been killed in efforts to stem its spread. Can bird flu be stopped, and if yes, how?'
'A single dose of doxycycline taken within 72 hours of unprotected sex dramatically cuts the risk of a bacterial S.T.I., studies have found. The approach seems most effective for preventing chlamydia and syphilis, and slightly less so for preventing gonorrhea.'
Great fun discussing classic immunology papers with @marcdionne's class at Imperial yesterday - but very happy to be doing it in person next week!
Thiago Carvalho
boosted
Under the lantern in Dresden, Germany 1935. Sotto al lampione.
Photo: Richard Peter. #BlackAndWhitePhotography
Thiago Carvalho
boosted
Pfizer CEO Albert Bourla maxed out campaign contributions to Dr. Oz ahead of midterm elections https://www.statnews.com/2023/03/09/pfizer-bourla-dr-oz/?utm_medium=social&utm_source=mastodon&utm_campaign=mastodon_organic
In AMR news:
"Multiple strains of the diarrhea-causing bacteria Shigella have acquired resistance to the five antibiotics most commonly used to treat it, a health alert released by the Centers for Disease Control and Prevention revealed last month."
#antibiotics #antibioticresistance
Thiago Carvalho
boosted
During proactive distractor suppression, the role of #alpha activity induced by spatial #distractor cues and its influence on subsequent distractor inhibition reveal how the brain engages in proactive filtering mechanisms #PLOSBiology https://plos.io/3F8rbDc
Thiago Carvalho
boosted
In 2019, bots submitted over a million comments opposing net neutrality. In my view, this man-in-the-middle attack on democracy has been one of the most under-discussed of the past decade.
Somehow I missed this piece from Nathan Sanders and Bruce Schneier on how LLMs will turbocharge the threat of similar exploits.
Thiago Carvalho
boosted
PhD in Cell biology, Protein trafficking and Microscopy @UNamur
Recruiting a PhD student to study the early secretory pathway and its modulation in health and disease using advanced microscopy
#ScienceJobs #job #PhD #Acade...
https://jobrxiv.org/job/university-of-namur-27778-phd-in-cell-biology-protein-trafficking-and-microscopy/?feed_id=40074
Thiago Carvalho
boosted
"Far from opening up the pandemic period to greater scrutiny, Hancock’s messages have merely flagged to his colleagues the importance of evading it."
@zoesqwilliams in the @Guardian
https://www.theguardian.com/commentisfree/2023/mar/08/matt-hancock-whatsapps?CMP=Share_AndroidApp_Other
'When presented to the immune system as either ex vivo-loaded dendritic cells or expressed from a viral vector, lncRNA-derived peptides drove a potent antigen-specific CD8 T lymphocyte response, which translated into a significant delay in tumour growth.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
