Thiago Carvalho @cyrilpedia@qoto.org

@gpollara @halama_immuno @EMIL_DKFZ
I was out for a while: which meeting?

Ciao Bologna

'Here, we identify the temporal window for type I interferon (IFN-I) receptor (IFNAR) blockade to drive TSCM cell generation. TSCM cells were transcriptionally distinct and emerged from a transitional precursor of exhausted (TPEX) cellular state concomitant with viral clearance.'
#Preprint #Immunology
https://www.biorxiv.org/content/10.1101/2024.06.26.600763v1

'Aged mice develop more hepatocyte ferroptosis and liver degeneration than young mice when fed diets that induce metabolic stress. Inhibiting ferroptosis shifts the liver transcriptome of old mice toward that of young mice and reverses aging-exacerbated liver damage, identifying ferroptosis as a tractable, conserved mechanism for aging-related tissue degeneration.'

https://www.nature.com/articles/s43587-024-00652-w

'We begin with the classic topics of gene regulation, pattern formation, morphogenesis, organogenesis, and regeneration and then highlight recent progress that connects developmental biology to metabolism, timing, ecology, evolution, self-organization, and human development.'

https://www.cell.com/cell/fulltext/S0092-8674(24)00632-9

'Neoliberal autoritário, Macron trabalhou para destruir todo o sistema partidário, criou uma força política em torno sua pessoa e impôs mudanças económicas e sociais radicais por decreto, passando sobre o parlamento. Mesmo a marcação destas eleições para três semanas depois para impedir a oposição de se preparar é democraticidade discutível. Macron não foi, durante estes anos, defensor da democracia francesa. Degradou-a e encaminhou-a para uma tragédia há muito anunciada. Agigantou a extrema-direita para ele ser o voto inevitável. Um dia aconteceria a extrema-direita chegar a esta votação e a alternativa deixar de ser ele. Foi ontem.'

https://expresso.pt/opiniao/2024-07-01-e-agora-o-voto-une-se-contra-a-maioria-absoluta-dos-herdeiros-de-vichy--0503ff41

'Paradoxically, in the process of illuminating these biological mysteries, human stem-cell-based modeling could recast much of what we take to be special about ourselves as simply a reproducible series of physical events. What does it mean for individuality, for example, if the early embryonic history of each cell line donor can be replayed again and again through the artificial generation of identical human embryo models?'
https://www.cell.com/cell/fulltext/S0092-8674(24)00537-3

"Who's a good dog?" is not a genetically simple question:

Dr. Karlsson’s own project, Darwin’s Dogs, is at 44,000 canines and counting. (Some 4,000 have had their genomes sequenced.) Researchers are mining the data for clues about bone cancer, compulsive behavior and other traits. Among the early findings: Although many behavioral traits, such as sociability and trainability, are heritable, they are widely distributed across the canine kingdom, and breed is a poor predictor of an individual dog’s personality.
https://www.nytimes.com/2024/06/30/science/pets-research-dogs-cats.html

'Pet owners rose to the challenge. The Golden Retriever Lifetime Study, which began recruiting in 2012, has been following more than 3,000 dogs in an effort to identify genetic and environmental risk factors for cancer, which is especially common in the breed.Since 2019, the Dog Aging Project, a long-term study of health and longevity, has enrolled nearly 50,000 dogs.'

https://www.nytimes.com/2024/06/30/science/pets-research-dogs-cats.html

"O problema da UE não está fora, mas dentro — como sempre esteve. Desde 2010 que a União tem uma crise de estado de direito, emblematizada por um Governo, o húngaro, de Viktor Orbán, que não só esvaziou a democracia em casa como dentro do Conselho Europeu faz o papel de submarino de Vladimir Putin."
@ruitavares
https://expresso.pt/opiniao/2024-06-27-a-europa-de-costa-a-contra-costa-bbf8b23b

'The desert is encroaching across Sicily, the largest and most populous island in the Mediterranean, where a European temperature high of 48.8C was recorded in 2021. Rainfall is down by more than 40% since 2003. In the last six months of 2023, just 150mm of rain fell.'

https://www.theguardian.com/world/article/2024/jul/01/drought-leaves-sicilian-farmers-facing-uncertain-future