Thiago Carvalho @cyrilpedia@qoto.org

'Twenty-nine different Car-T treatments for autoimmune diseases, ranging from the muscle inflammation condition myositis to multiple sclerosis, are now being tested in clinical trials by drugmakers including Novartis and Bristol Myers Squibb'

#Immunology #Autoimmunity #CARTcells

https://www.ft.com/content/a974f4c1-bb8a-4a1b-9d88-a2cf14be5c6e

'Under the publication conditions presented above, we claim that the current publication system can distort Open Science, by presenting a vision of Open Science that fails to consider the need for quality inherent in scientific production. We especially argue that scientific publishers, but also institutions, tend to confound Open Science and Open Access, underfunding the quality control of data while overfunding Open Access, without sufficiently consulting the researcher community on global scientific objectives. We call for greater cautiousness when dealing with the promotion of Open Science, and a stronger reliance on Open Science practices by and for researchers instead of by institutions and publishers and for publishers.'
https://open-research-europe.ec.europa.eu/articles/4-127/v1

' Japanese disaster food — which also goes by the names bōsaishoku (disaster-prevention food), bichikushoku (food reserves), hozonshoku (preserved food), and hijōshoku (emergency food) — is wonderfully diverse. There’s dehydrated mushroom risotto, freeze-dried chicken stew, and canned mackerel in miso and sesame. Ready-to-eat food packets range from Japanese classics like nikujaga (beef and potato stew), oden (fish cakes and vegetables in savory-sweet broth), and curry to more globally recognizable dishes like pasta carbonara and beef stroganoff. Some meals come with a built-in heating unit. One company claims that its meals will keep for 25 years. For dessert, there’s Toyo Foods’ canned matcha cheesecake, Izameshi’s anko mochi (pounded rice cakes with sweet red bean paste), or Imuraya’s yōkan (sweet jellied red bean paste), which won an award from the Disaster Prevention Safety Association.'

https://www.eater.com/24194897/japan-saigaishoku-disaster-food-emergency-rations

“I know you’re trying to skirt around it,” says Benjamín Labatut when I put to him that his books concern people of unworldly intelligence working on problems that are maximally deep, “but the best way to sum it up is: ‘Why am I interested in mad scientists?’” Fair play. There’s no getting away from it: that’s exactly what his richly satisfying, deeply researched books are about.'

https://www.theguardian.com/books/article/2024/jul/13/people-say-my-book-gave-them-a-panic-attack-when-we-cease-to-understand-the-world-author-benjamin-labatut

'Male and female humans are born with the same number of cardiomyocytes — the predominant cardiac cell type by mass; however, in adulthood, males have a significantly smaller proportion of cardiomyocytes. This is thought to be due to testosterone-induced apoptosis in the male heart, although differences in cardiomyocyte-regenerative capacity may also contribute.'
https://www.jci.org/articles/view/180074

'In June I was helping to manage a community outbreak of whooping cough when the whole town ran out of clarithromycin suspension, the recommended antibiotic for the acute phase in children. None could be found, and I was reduced to asking the parents of affected children to get a pestle and mortar to grind up tablets and hide the powder in yoghurt. A few months ago we had an outbreak of scarlet fever and did the same with tablets of penicillin. The pestle and mortar is one of the oldest symbols of the pharmaceutical profession; it’s an unexpected twist in the spiralling problems of the health service that in 2024 we’re having to recommend returning to it.'

https://www.lrb.co.uk/the-paper/v46/n14/gavin-francis/short-cuts

'De seguida, para quem acredita na capacidade de oposição da academia, da função pública ou dos media a uma deriva autoritária, também aqui o exemplo húngaro nos deve abrir os olhos. O que parecia impossível, aconteceu: há universidades que saíram do país ou foram aparelhadas por fiéis partidários, há jornais que foram fechados de uma semana para a outra ou comprados pelos “amigos” do primeiro-ministro, e os altos funcionários públicos habituaram-se a ter de viver com testes de lealdade e a admitir escutas telefónicas aleatórias durante x meses a cada x anos, que nunca sabem exatamente quais são, e que são autorizadas diretamente pelo ministro da Justiça.'
@ruitavares
https://expresso.pt/opiniao/2024-07-11-isto-nao-e-um-teste.-se-fosse-estariamos-a-chumbar-7606d9ec

'The Build-A-Genome course was developed to teach students basic practical molecular genetics while also providing the raw materials for a global genome synthesis project, Yeast 2.0. The course evolved over two decades to reflect the changing needs and opportunities for the project and the development of new technologies. In addition to educating a generation of college and high school students in a new way, it also developed a cadre of educators who developed similar courses and projects at a wide variety of research and educational institutions.'
https://academic.oup.com/genetics/advance-article/doi/10.1093/genetics/iyae083/7710319?searchresult=1