"Elon Musk’s Daughter Fires Back at Father Over ‘Dead’ Comments: ‘Desperate For Attention’ From ‘Degenerate Red-Pilled Incels’"
“Behind the cotton wool is hidden a pattern…the whole world is a work of art…there is no Shakespeare…no Beethoven…no God; we are the words; we are the music; we are the thing itself.”
Virginia Woolf's exquisite epiphany on creativity https://t.co/riynGV93mp
What to know about the updated COVID-19 vaccines coming this fall.
ABC News reports "the [U.S.] Centers for Disease Control and Prevention recommended Americans receive the updated 2024-25 vaccine when it becomes available later this year."
#COVID #COVID19 #Vaccines #Pandemic #Disease #Medicine #Health
“Best Paper” awards lack transparency, inclusivity, and support for Open Science. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002715. A really enjoyable 'big science' project led by Losia Lagisz.
How information is processed in the brain when consciousness is lost due to anaesthesia or brain injury. #Neuroscience https://elifesciences.org/digests/88173/understanding-consciousness?utm_source=mastodon&utm_medium=social&utm_campaign=organic
'Pacific islands were among the last places that the pandemic touched due to their isolation with few ships available at the end of the First World War. One island steamer from New Zealand, the SS Talune, has the dubious distinction of having brought lethal influenza to Fiji, Samoa and Tonga in late 1918'
https://jmvh.org/article/pacific-island-societies-destabilised-by-infectious-diseases/
Insight into the Interaction between Neuronal Calcium Sensors and Insulin https://www.biorxiv.org/content/10.1101/2024.07.26.605271v1?med=mas
Adaptive resistance to FLT3 inhibitors is potentiated by ROS-driven DNA repair signalling https://www.biorxiv.org/content/10.1101/2024.07.26.605229v1?med=mas
'A European Medicines Agency committee on Friday recommended that Leqembi should be denied a marketing authorisation in the EU, severely knocking the likelihood of approval for use in the 27-member bloc. The neurodegenerative condition affects about 50mn people worldwide.'
https://www.ft.com/content/27eafb84-f8b0-428a-a275-f38e66ef8961
Interesting, but that's a big 'if':
“They support the hypothesis that vaccination against shingles might prevent dementia,” Taquet said. “If validated in clinical trials, these findings could have significant implications for older adults, health services and public health.”
https://www.ft.com/content/d0aaf521-8f24-444d-86b7-c260ae7909a6
'So far, 17 seals have tested positive for the virus, said Tess Gridley, a founding director of Sea Search Research and Conservation, who has been investigating the seal deaths. The cases, which date back to at least August 2022 and span hundreds of miles of coastline, may be the first sustained rabies outbreak ever documented in marine mammals.'
https://www.nytimes.com/2024/07/25/health/rabies-cape-fur-seals-south-africa.html
In #Illinois, a police officer shot Sonya Massey and killed her. He has been charged with murder. The facts will come out at trial, but the choice for the election is clear. Kamala #Harris wants to hold cops accountable when they break the law. Donald #Trump wants to give them immunity from prosecution. A decision to stay home means you're OK with letting the cop who killed Sonya Massey stay home. Silence means consent. https://www.msnbc.com/the-reidout/reidout-blog/sonya-massey-police-accountability-trump-harris-rcna163741?cid=eml_mda_20240726&user_email=6178f1b4ffd352f367e7b15ac9f42f239b7166116dfcd896d93afa99a5de221d
'Despite these key cellular effects of Aβ, and its essential role in AD, the traditional assumption that neurons are the primary source of pathogenic Aβ in the brain has remained untested. In this study, we show that oligodendrocytes in human tissue contain all of the components required to produce Aβ, and that human oligodendrocytes produce soluble Aβ in vitro. We further show that selectively suppressing oligodendrocyte Aβ production in an AD mouse model is sufficient to rescue abnormal neuronal hyperactivity.'
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002727
'New readers are often caught breathless when they read about a presidential candidate (a zealot) running on the pledge to “make America great again” in Butler’s sequel to Parable of the Sower, Parable of the Talents which was published in 1995.'
https://lithub.com/on-the-simple-prophecy-of-octavia-butlers-parable-of-the-sower/
'But we also saw other methods of speciation that Darwin hadn’t anticipated involving the rare hybridisation (or interbreeding) of species – including the formation of an entirely new lineage. This remarkable and unexpected process began with the arrival of a single male large cactus finch (Geospiza conirostris) on Daphne from an island in the far south of the archipelago. Though whether the lineage ultimately succeeds or succumbs remains to be seen.'
https://www.theguardian.com/science/article/2024/jul/21/rosemary-grant-peter-grant-charles-darwin-finches-evolutionary-biology-princeton-one-step-sideways-three-steps-forward-memoir
'While Japan lacks its own homegrown AI giants, some tech companies are drawn to the market for another reason: the country’s copyright law which critics say allows widespread use of copyrighted images and other materials for commercial purposes to train AI models without seeking permission.'
https://www.ft.com/content/f9e7f628-4048-457e-b064-68e0eeea1e39
'In this review of a diverse literature, we show how host control mechanisms influence almost every aspect of microbiome biology. Our focus is the mammalian microbiome, but we also examine well-characterized examples from invertebrate and plant microbiomes. To begin, we explore the biology of host control, including immunity, barrier function, physiological homeostasis, transit, and host behavior.'
https://www.science.org/doi/10.1126/science.adi3338
'We unexpectedly found that cRel abundance and B cell proliferation are not proportional, but have a complex relationship in which some characteristics of proliferative clonal expansion are enhanced by cRel but others are diminished. We show that this may underlie the proliferation phenotypes of marginal zone vs. follicular B cell subsets.'
#Immunology
https://www.pnas.org/doi/10.1073/pnas.2309686121
Finally!
David Simon, Andre Braugher, and Barry Levinson... Homicide is a masterpiece
'A história traz um final feliz. Carlo Croce perdeu os processos e ainda teve uma dezena de artigos retirados de publicação. Mas mostra os riscos desta profissão em part-time. Os processos são morosos e dispendiosos – no caso de David Sanders, a Universidade Purdue assegurou as despesas – e isso pode amedrontar quem quer denunciar más práticas na ciência. Não é por acaso que a maioria dos que escrevem em fóruns como o PubPeer, dedicado à discussão de problemas nos trabalhos científicos, o fazem sob pseudónimo. Ninguém quer desacreditar a ciência. Pelo contrário, querem aparar e tirar a erva daninha.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com