'Alguns dos problemas decorrentes de um crescimento excessivo do turismo são evidentes e bem conhecidos de toda a população. A OCDE alerta para aspectos como as pressões sobre os preços do alojamento (que dificultam o acesso à habitação dos residentes e também dos trabalhadores sazonais), sobre as infra-estruturas e os serviços colectivos (traduzindo-se, por exemplo, na sobrelotação dos transportes públicos ou na acumulação de lixo nas zonas mais frequentadas) e sobre o ambiente (aumentando a poluição e pondo em causa a sustentabilidade dos ecossistemas e a biodiversidade). Os crescentes protestos populares em zonas de grande intensidade turística – como Barcelona ou Málaga, para dar dois exemplos recentes – são um sinal de que o excesso de turismo existe de facto e que está a tornar-se um problema político sério em diferentes partes do mundo.'
https://www.publico.pt/2024/07/29/opiniao/opiniao/vamos-assumir-turismo-tornou-problema-2099079
'We demonstrate the first generalizable strategy using a small molecule to selectively kill TP53 mutant cells. This molecule binds the Y220C mutant of p53 and concentrates a PLK1 inhibitor in cells harboring TP53 Y220C mutations.'
#Preprint
https://www.biorxiv.org/content/10.1101/2024.07.27.605429v1
'Hungary this month published details of a new fast-track visa system for citizens of eight countries, including Russia and Belarus, to enter Hungary without security checks or other restrictions. Budapest said many would be building a nuclear power plant with Russian technology. '
https://www.ft.com/content/b2a4ebd8-df41-43fe-8d63-602c1d50e899
VONNEGUT
There has to be. Because you can lose a reader in a blink of an eye. If a person is an engineer or chemist or an anthropologist or whatever, you spoil the whole book for that person if there’s obviously ignorance here. What’s wrong with so much science fiction is that the science is so lousy that it isn’t worth paying attention to. My brother was a distinguished scientist and I hung out more with scientists than I did with writers, so the one thing I’ve always tried to do was to get it right, make it plausible. Scientifically. How long it takes to get somewhere through space and what you ‘re likely to find there, and you have to figure whether it’s going to be plausible or not. So, yeah, I did a book called Galapagos which was about evolution and it’s used in courses now.
https://www.robertcaro.org/post/an-interview-with-robert-caro-and-kurt-vonnegut
'We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin-10 signaling.'
#Immunology #Autoimmunity
Gene transfer of human cardiomyopathy beta-MyHC mutant R403Qdirectly alters intact cardiac myocyte calcium homeostasis and causes hyper-contractility https://www.biorxiv.org/content/10.1101/2024.07.31.605903v1?med=mas
"Old Arabic texts introduce medieval Europe to the significance of foreplay, kissing, and pillow talk."
https://thereader.mitpress.mit.edu/sex-and-female-semen-in-the-medieval-arab-world/
'Atomic People does not mark a major anniversary. It is simply that time is running out for the long-silent survivors to tell their stories, to have them heard and to let them function – insofar as is possible in this war-ravaged world – as a warning from history.'
'Our country never made the requisite investments in clean air upgrades for buildings. Despite botching our vaccination campaigns, we have refused to impose universal Covid safety rules for workplaces. Although one of the earliest recommendations from the World Health Organization was to remove financial barriers to care, our country still doesn’t have a universal healthcare system. We have even watched millions of Americans get stripped from the Medicaid rolls, while 10 states still refuse to expand Medicaid eligibility. Meanwhile less than half of states have guaranteed paid medical leave.'
@gregggonsalves
https://www.thenation.com/article/society/why-covid-keeps-winning/
'For many people, a routine blood test is easier to get than a colonoscopy or a fecal sample test. But the blood test, made by Guardant Health of Palo Alto, Calif., comes with a limitation. Unlike other screening tests for colon and rectal cancers, it has a poor record of finding precancerous growths. Removal of those growths can prevent cancer.'
https://www.nytimes.com/2024/07/29/health/colon-cancer-blood-test-shield.html
Botanists vote to change derogatory and racist scientific plant names : NPR https://www.npr.org/2024/07/31/g-s1-14441/renaming-racist-derogatory-plant-names-science-society-inclusion
“The incidence of common arterial thrombotic events (mainly #AcuteMyocardialInfarction and ischaemic #stroke) was generally lower after each vaccine dose, brand and combination. Similarly, the incidence of common venous thrombotic events, (mainly #PulmonaryEmbolism and lower limb #DeepVenousThrombosis) was lower after #vaccination. #COVID19Vaccines #VaccinesWork https://mstdn.social/@erictopol/112881520511875953
‘
"We know that the source of the problem is probably the warming of the sea surface temperature in the Gulf of St. Lawrence because it seems like most of the rivers that run into the gulf are more affected than other rivers."
‘
https://www.cbc.ca/news/canada/montreal/quebec-salmon-restrictions-1.7280694
I wrote about physicist Sara Walker's travels in the border zones of life in my 2021 book "Life's Edge." Now she has written a book of her own. Here's my story on "Life As No One Knows It." Gift link: https://nyti.ms/4fueKlU
“We’re half an hour in, and they’ve still only made it to Masculin Féminin,” said three-time Olympic medalist Lebron James, speaking for the majority of the 10,500 athletes in attendance'
https://www.theonion.com/paris-opening-ceremony-features-tedious-45-minute-discu-1851601939
Testing GLP-1s in Alzheimer's, and is Medicare a good negotiator?
'The (Gates) foundation has partnered with the publisher F1000—which is known for carrying out postpublication peer review—to launch VeriXiv, a new platform of verified preprints. VeriXiv promises to conduct 20 ethics and integrity checks to ensure that papers meet basic quality requirements.'
https://cen.acs.org/policy/publishing/future-science-publishing/102/i23
STAT+: Older GLP-1 drug may help protect brains of Alzheimer's patients, early study suggests
'Our country never made the requisite investments in clean air upgrades for buildings. Despite botching our vaccination campaigns, we have refused to impose universal Covid safety rules for workplaces. Although one of the earliest recommendations from the World Health Organization was to remove financial barriers to care, our country still doesn’t have a universal healthcare system. We have even watched millions of Americans get stripped from the Medicaid rolls, while 10 states still refuse to expand Medicaid eligibility. Meanwhile less than half of states have guaranteed paid medical leave.'
@gregggonsalves
https://www.thenation.com/article/society/why-covid-keeps-winning/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com