Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Issue 17 is complete!
On the cover: A small hematopoietic progenitor polarizing on a large osteoblast in a microwell. Blue indicates the nuclei. Orange and yellow indicate actin and microtubules for z-stacks containing the progenitor. See Candelas et al.
Also in Issue 17:
▪️6 Research Highlights
▪️2 Perspectives on human #DevBio
▪️4 People behind the papers interviews
▪️Review on axon termination in mechanosensory neurons
"We Americans tend to think that freedom is a matter of things being cleared away, and that capitalism does that work for us. It is a trap to believe in this,” he writes. “Freedom is not an absence but a presence, a life in which we choose multiple commitments and realize combinations of them in the world.”
https://www.vanityfair.com/news/story/timothy-snyder-american-fascism-under-trump
Thiago Carvalho
boosted
Restoration in the temple of Edfu reveals new inscriptions, paint, and gold
https://phys.org/news/2024-09-temple-edfu-reveals-inscriptions-gold.html
Hilarious hijinx did not ensue
'Capitalism’s radical critics (Vladimir Lenin) and radical supporters (Friedrich Hayek) agreed that monopoly meant oppression. Markets are supposed to enable competition, spread information, and separate economics from politics. But what would happen when giant Soviet enterprises came into private hands?'
https://lithub.com/timothy-snyder-on-how-the-collapse-of-the-soviet-union-took-america-by-surprise/
Thiago Carvalho
boosted
Timothy Snyder Explains How Americans Might Adapt to Fascism Under Trump
https://www.vanityfair.com/news/story/timothy-snyder-american-fascism-under-trump
Thiago Carvalho
boosted
The Brooklyn Potluck That Helped Black Literature Flourish
https://www.thenation.com/article/culture/the-sisterhood-courtney-thorsson/#respond
Thiago Carvalho
boosted
Hidden in a piece for the FT, it seems for Jeremy Hunt the penny has finally dropped about how the Tories crashed & burned in the last election, he notes in his piece warning Reeves not to sacrifice growth (rich from a man whose party oversaw years of economic stagnation), that:
'what matters to ordinary families is good jobs & rising living standards'.
And what did the Tories deliver: rubbish precarious jobs & falling living standards.
Looks like he did get the message.
'To elucidate the in vivo function of neoself-antigens presented on MHC-II by decreased Ii expression, we analyzed the antigen specificity of clonally expanded autoreactive T cells in SLE patients as well as in drug-inducible Ii knockout (Ii-iKO) mice, which allowed us to delete the Ii from adult mice. We demonstrate that neoself-antigens presented on MHC-II upon decreases in Ii expression levels are recognized by CD4+ T cells as non-self-antigens and are the primary targets for autoreactive T cells clonally expanded in SLE patients. Furthermore, we suggested that EBV reactivation, which downregulates Ii expression, could be involved in the activation of neoself-reactive T cells.'
#Immunology #Autoimmunity
https://www.sciencedirect.com/science/article/abs/pii/S0092867424009139
Thiago Carvalho
boosted
Just four companies in the U.S. control:
85% of beef processing
80% of corn seed distribution
77% of fertilizer production
69% of grocery sales
Wondering why food prices are so high?
Minimal competition means maximized price-gouging.
Thiago Carvalho
boosted
"A small, cloistered elite of not-especially-bright billionaires have decided that they are very, very special, and that the problem with society these days is that people keep treating them like everyone else. "
(Original title: Paul Graham and the Cult of the Founder)
https://davekarpf.substack.com/p/paul-graham-and-the-cult-of-the-founder
Thiago Carvalho
boosted
Postdoctoral Research Associate
https://botany.fyi/udc7cd
The University of Edinburgh is looking for a Post-Doctoral Research Associate to study the evolution and genetic regulation of phyllotaxis in the lycophyte lineage in the group of Dr Sandy Hetherington (The Molecular Palaeobotany and Evolution Group)
#PlantSciJobs @plantscijobs
Thiago Carvalho
boosted
After 2 years of war #ScienceForUkraine is still needed - some great initiatives here.
Thiago Carvalho
boosted
The ethereal beauty of Florent Grau's "Galerij van Apollo" transports viewers to the opulent court of Saint-Cloud. The intricate details and vibrant palette invite contemplation. How does this artwork reshape your perception of 19th-century artistry?
#Rijksmuseum #FlorentGrau #ArtHistory
https://www.rijksmuseum.nl/nl/collectie/RP-F-F09569
"Here, through in vivo and ex vivo isotopic tracing, we examined the contributions of different nutrients to neutrophil metabolism under specific conditions. Human peripheral blood neutrophils, in contrast to a neutrophil-like cell line, rely on glycogen storage as a major metabolic source under resting state but rapidly switch to primarily using extracellular glucose upon activation with various stimuli."
#Immunology #Metabolism
https://www.pnas.org/doi/10.1073/pnas.2321212121
Thiago Carvalho
boosted
European Commission cuts funding support for Free Software projects https://edri.org/our-work/european-commission-cuts-funding-support-for-free-software-projects/
Terrible idea, and all the more terrible because this happens for the wrong reasons.
Thiago Carvalho
boosted
Post-Doctoral Fellowship in Chemistry
University of Sao Paulo
Post-Doctoral Fellowship in Chemistry
Project: Characterization of ditryptophan and tryptophan-tyrosine cross-links
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-sao-paulo-27778-post-doctoral-fellowship-in-chemistry/?feed_id=82550
#biochemistry #chemistry #ditryptophan_tryptophan_tyrosine ...
https://jobrxiv.org/job/university-of-sao-paulo-27778-post-doctoral-fellowship-in-chemistry/?feed_id=82550
'Contrary to public perception, we observe considerably lower felony arrest rates among undocumented immigrants compared to legal immigrants and native-born US citizens and find no evidence that undocumented criminality has increased in recent years'
https://www.pnas.org/doi/10.1073/pnas.2014704117
'Last December, the Food and Drug Administration gave approvalto two companies, Bluebird Bio of Somerville, Mass., and Vertex Pharmaceuticals of Boston, to sell the first gene therapies approved for sickle cell disease. After nine months, Kendric remains the first Bluebird patient to progress this far, with at least a few others advancing toward his pace.'
#SickleCell #GeneTherapy
https://www.nytimes.com/2024/09/16/health/sickle-cell-gene-therapy-kendric-cromer.html
Thiago Carvalho
boosted
The Brazilian military has been involved in a series of controversial episodes that have undermined emergency efforts to tackle the humanitarian crisis in the Yanomami Indigenous Territory.
Reports show it failed (or sabotaged) airspace control and food deliveries to the Indigenous people, who suffer from malnutrition as a result of mercury contamination from illegal mining.
By André Schröder
https://news.mongabay.com/2024/09/how-the-brazilian-military-sabotaged-protection-of-indigenous-people-in-the-amazon/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
