Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Another end-of-civilisation-as-we-know-it crops up in Moths (Angry Robot, £9.99), an invigorating debut by Jane Hennigan. This time the culprit is a hitherto unknown species of moth whose caterpillars spread tiny noxious threads that have an adverse effect on male humans, causing half to die and the rest to go homicidally — and often misogynistically — insane.'
https://www.ft.com/content/8fb6b85d-d499-4bfb-8d4d-54da23969792
AI in breast cancer screening.
"Advancements in A.I. are beginning to deliver breakthroughs in breast cancer screening by detecting the signs that doctors miss. So far, the technology is showing an impressive ability to spot cancer at least as well as human radiologists, according to early results and radiologists, in what is one of the most tangible signs to date of how A.I. can improve public health."
https://www.nytimes.com/2023/03/05/technology/artificial-intelligence-breast-cancer-detection.html
"Stipends available! Apply for the Chen Science Writer Award or a stipend to attend the FENS–Chen Institute –NeuroLéman #SummerSchool!
Don’t miss this #training opportunity and apply before the deadline, 13 March."
Maybe it's better to talk about ending silent exploitation.
“Quiet quitting has such a negative connotation; it makes you feel even worse.” Many researchers disdain the term, noting that they’re neither quitting nor being quiet about their desire to create healthier work–life boundaries, prioritize their mental health and reject toxic workplace cultures.'
Thiago Carvalho
boosted
This is not a drill.
The nightmare scenario for personal privacy in a world where women are stripped of their reproductive rights is coming to pass:
Meta, Google, other tech companies are providing police with evidence to help prosecute women who seek or perform abortions
Thiago Carvalho
boosted
Watch Anthony Bourdain’s First Food-and-Travel Series "A Cook’s Tour" Free Online (2002-03)
Thiago Carvalho
boosted
I study #immune #evolution, including host - #pathogen interactions. My work has focused on #antimicrobial #defense #peptides which are like #antibiotics coded by the #genome . A key focus is #immunity-#microbiome interactions 🦠
New PP: https://doi.org/10.1101/2022.12.23.521774
I also talk ethical publishing and advancing the conversation on #preprint, #openscience, and #academicchatter.
Thiago Carvalho
boosted
MSCA Postdoctoral fellow in evolutionary/functional genomics @marie_saitou
#ScienceJobs #job
Ås, Viken #Norway #PostdoctoralFellow
https://jobrxiv.org/job/norwegian-university-of-life-sciences-marie-saitou-group-27778-msca-postdoctoral-fellow-in-evolutionary-functional-genomics/?feed_id=39810
"We collected 48 faecal samples from all but one of the 17 bat species breeding in the UK, through an extensive network of bat rehabilitators and conservationists, and screened them for coronaviruses using deep RNA sequencing."
#preprint https://www.biorxiv.org/content/10.1101/2023.01.17.524183v3
“The major advantage of NK cells is they’ve never killed anybody, unlike CAR-T cells,” says Lewis Lanier of the University of California, San Francisco, and the Parker Institute of Cancer Immunotherapy, who has pioneered research into the NK cell biology over the past 40 years. For reasons that are not fully understood, cytokine release syndrome, if it occurs during NK cell therapy, tends to be much milder.'
"An investigation by ProPublica found online pharmacies that sell abortion medication such as mifepristone and misoprostol are sharing sensitive data, including users' web addresses, relative location, and search data, with Google and other third-party sites — which allows the data to be recoverable through law enforcement requests."
Thiago Carvalho
boosted
Facebook and Google are handing over user data to help police prosecute abortion seekers.
One legal expert said social platforms may cooperate with police even if not legally required to.
Thiago Carvalho
boosted
The way the immune system protects the body’s cells from cytotoxic T cells also makes these killer cells worse at eliminating cancer. https://elifesciences.org/digests/79342/keeping-killer-t-cells-in-check?utm_source=mastodon&utm_medium=social&utm_campaign=organic
'This delicate process—following and developing the master’s path by criticizing the master—has a precise beginning in the history of human thought: the position that Anaximander assumed vis‑à‑vis his master Thales.'
https://lithub.com/when-rebellion-becomes-virtue-how-the-scientific-method-came-to-be/
Thiago Carvalho
boosted
This week's highlightable delights: How to survive hopelessness, Einstein on free will and the power of the imagination, our search for meaning in the age of AI https://mailchi.mp/themarginalian/hopelessness-free-will-ai
Thiago Carvalho
boosted
New #preprint: https://t.co/9MeQR16lYh "Darwin’s Agential Materials: evolutionary implications of multi-scale competency in developmental biology"
Previously, I argued for morphogenesis as a kind of collective intelligence navigating anatomical morphospace + ways in which evolution scales up from single cells' tiny goals to agents w/ larger goals (e.g., specific target morphologies). Here, I ponder: what does the competency of the morphogenetic layer mean for the evolutionary process itself?
"However, we find that there is consistently a stronger relationship between mRNA abundance and gene sensitivity than there is between regulatory gene activity and gene sensitivity. This is true both when gene sensitivity is treated as a binary and a quantitative property. Overall, our results suggest that gene sensitivity is better predicted by measured expression than by GRN-inferred activity."
'Blockade of the inhibitory FcγRIIB in combination with anti–PD-L1 improved antitumor responses. Similarly, afucosylation of the IgG1 Fc region improved antitumor responses, and this was due to alterations in the tumor microenvironment.'
When your frenemies get the last word.
(from "Apropos of Nothing in the NYRB https://www.nybooks.com/articles/2022/07/21/absence-and-nothing-stephen-mumford/ )
My favorite case in the history of biology is Cuvier's eulogy of Lamarck, which you can read 👇
https://victorianweb.org/science/science_texts/cuvier/cuvier_on_lamarck.htm
Thiago Carvalho
boosted
Carl Sagan - "It is well within our power to destroy our civilization and perhaps our species as well.
If we capitulate to superstition or greed or stupidity, we can plunge our world into a darkness ...
But we are also capable of using our compassion and our intelligence, our technology and our wealth, to make an abundant and meaningful life for every inhabitant of this planet, to enhance enormously our understanding of the universe and to carry us to the stars."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
