Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
In AMR news:
"Multiple strains of the diarrhea-causing bacteria Shigella have acquired resistance to the five antibiotics most commonly used to treat it, a health alert released by the Centers for Disease Control and Prevention revealed last month."
#antibiotics #antibioticresistance
Thiago Carvalho
boosted
During proactive distractor suppression, the role of #alpha activity induced by spatial #distractor cues and its influence on subsequent distractor inhibition reveal how the brain engages in proactive filtering mechanisms #PLOSBiology https://plos.io/3F8rbDc
Thiago Carvalho
boosted
In 2019, bots submitted over a million comments opposing net neutrality. In my view, this man-in-the-middle attack on democracy has been one of the most under-discussed of the past decade.
Somehow I missed this piece from Nathan Sanders and Bruce Schneier on how LLMs will turbocharge the threat of similar exploits.
Thiago Carvalho
boosted
PhD in Cell biology, Protein trafficking and Microscopy @UNamur
Recruiting a PhD student to study the early secretory pathway and its modulation in health and disease using advanced microscopy
#ScienceJobs #job #PhD #Acade...
https://jobrxiv.org/job/university-of-namur-27778-phd-in-cell-biology-protein-trafficking-and-microscopy/?feed_id=40074
Thiago Carvalho
boosted
"Far from opening up the pandemic period to greater scrutiny, Hancock’s messages have merely flagged to his colleagues the importance of evading it."
@zoesqwilliams in the @Guardian
https://www.theguardian.com/commentisfree/2023/mar/08/matt-hancock-whatsapps?CMP=Share_AndroidApp_Other
'When presented to the immune system as either ex vivo-loaded dendritic cells or expressed from a viral vector, lncRNA-derived peptides drove a potent antigen-specific CD8 T lymphocyte response, which translated into a significant delay in tumour growth.'
Thiago Carvalho
boosted
Bacterial #persister resuscitation is a drug-dependent & non-stochastic process. Persisters can partition into healthy &non-viable daughter cells to survive antibiotic treatment ➡️ http://bit.ly/3YlmzQV KR Allison @emoryuniversity #antibioticresistance #dynamics #QBio #SystemsBiology
Thiago Carvalho
boosted
Next chapter in our 2023 RNA review series:
Nikolaos Stamidis & Jan Zylicz explain RNA-mediated heterochromatin formation at repetitive elements in mammals
https://www.embopress.org/doi/10.15252/embj.2022111717
Origin stories:
"I asked (Bert Vogelstein & Ken Kinzler), 'What prompted you to hire a naive undergraduate from Australia?'
I'd put on my CV 'hobbies: bushwalking', which is hiking in Australian.
They said that they were so intrigued by someone who bushwalked that they needed to meet me."
Tracy Bryan, co-discoverer of ALT, a classic @embojournal paper, on the #EMBOPodcast
Thiago Carvalho
boosted
Illustration by Madalena Parreira for an interview I did with @matthewcobb a few years ago (a really interesting conversation about how he began writing non-technical books, "Then I suddenly came up with this idea of rather than write the biography, why not concentrate on this huge row that broke out in 1672 over who was the first to discover that women have eggs?")
Thiago Carvalho
boosted
Thiago Carvalho
boosted
"I think it was the first time that he had been to Africa, and health care workers had nothing but their bare hands. They could offer so little to alleviate the suffering. And I feel that that visit for Tony was quite transformative, and he appreciated that something could be done about it. That this was not an impossible situation, that we had the tools, the resources, and it just would take the will and the commitment to be able to change the reality of HIV in Africa."
https://www.nejm.org/doi/full/10.1056/NEJMp2300937?query=featured_home
"I think it was the first time that he had been to Africa, and health care workers had nothing but their bare hands. They could offer so little to alleviate the suffering. And I feel that that visit for Tony was quite transformative, and he appreciated that something could be done about it. That this was not an impossible situation, that we had the tools, the resources, and it just would take the will and the commitment to be able to change the reality of HIV in Africa."
https://www.nejm.org/doi/full/10.1056/NEJMp2300937?query=featured_home
Thiago Carvalho
boosted
Our March issue is online!
This month’s cover highlights 2 articles on #GutMicrobiota dysfunctions in #myopathies.
Read also our review on peritoneal metastases & articles on a new PDX model for #melanoma, #AlcoholicLiverInjury, infancy-onset #diabetes, #MultipleSulfataseDeficiency, #Artemisinin in #BrainTumors & much more!
🗞️ Fully #openaccess: https://www.embopress.org/toc/17574684/2023/15/3
'n this study, we provide evidence that direct sensing of the cytokine IFN-γ by CD8+ T-cells is a factor controlling the integration of T-cell affinity and differentiation during infection.'
https://www.biorxiv.org/content/10.1101/2023.03.06.531375v1?med=mas
Thiago Carvalho
boosted
Among our first #ReviewedPreprints, this study suggests that #Drosophila experience two hunger states – one driven by need and the other by pleasure – which arise from unique neural mechanisms. #Neuroscience #OpenScience #Preprints https://elifesciences.org/reviewed-preprints/84537v1?utm_source=mastodon&utm_medium=social&utm_campaign=organic_pr
Thiago Carvalho
boosted
Here is a fantastic Story! 👇
https://www.nature.com/articles/s41586-023-05770-
@FrezzaLab and colleagues show how fumarate causes the release of mtDNA to trigger innate immunity
Especially happy to see the incredible science coming from a kind and mindful colleague and role model @FrezzaLab 👏👏🔥
Thiago Carvalho
boosted
RT @ZugRoman
@dynlacht @WallaceUCSF In their 2018 @AnnualReviews paper "Development and Evolutionary Constraints in Animals", Galis, Metz and van Alphen devote a whole section to this question, entitled "An ancient metazoan constraint: cells cannot divide while differentiated".
https://www.annualreviews.org/doi/full/10.1146/annurev-ecolsys-110617-062339
Thiago Carvalho
boosted
How one medical school became remarkably diverse — without considering race in admissions https://www.statnews.com/2023/03/07/how-one-medical-school-became-remarkably-diverse-without-considering-race/?utm_medium=social&utm_source=mastodon&utm_campaign=mastodon_organic
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
