Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Olive trees in the bright March sun.
#photo #photography #photooftheday #smartphonephotography #umbria #italy #landscapephotography #landscape #BlackAndWhitePhotograghy #PhotographyIsArt #ArtistsOnMastodon
Thiago Carvalho
boosted
Illegal migration bill is ‘cruelty without purpose’, says Archbishop of York.
Jewish leaders join Stephen Cottrell in urging government not to penalise ‘world’s most vulnerable’ as charities and businesses voice horror in open letter.
Currently listening to: Tokyo funk sessions 2022
Thiago Carvalho
boosted
RT @extremetemps
Heat wave in SW Europe and Morocco
Today 10 March temperatures rose above 35C in Morocco and 30C in Spain but this is just the beginning of an exceptional warm spell which will trigger much >30C tomorrow in several areas of Spain with the warmth than spreading to Southern France
Thiago Carvalho
boosted
How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?
Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase
"Our data provide a model where the global shutdown of protein synthesis and subsequent rebooting mediated by miR-10b-5p downregulation is a hallmark of the dedifferentiation stage of limb regeneration."
@enirenberg There are many forms of autoreactivity that are part of healthy physiology - from housekeeping natural abs to regulatory T cells.
Thiago Carvalho
boosted
An autoimmune disease is defined by the fact that it is a DISEASE. It must create some kind of meaningful physiological disturbance (screenshots from Mackay and Rose's The Autoimmune Diseases 6th edition). Autoreactivity (reactivity to self) does not an autoimmune disease make.
Thiago Carvalho
boosted
With Jan Löwe and Kasim Sader, we are recruiting two Postdoctoral Scientists to work on #cryoEM specimen preparation:
Closing Date : 10 Apr 2023
More info : https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/2095-Postdoctoral-Scientist-Structural-Studies-Dr-Chris-Russo-LMB-2095/en-GB. More info : https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/2097-Postdoctoral-Scientist-Structural-Studies-Dr-Jan-L%C3%B6we-LMB-2097/en-GB.
Margaret Atwood's epiphany (fm her book On Writers and Writing).
Thiago Carvalho
boosted
Pseudomonas aeruginosa infection model with 2D airway organoids + RNAseq
-bioRxiv from Jeroen den Hertog @_Hubrecht @LeidenBiology
---
RT @biorxiv_micrbio
Establishment and characterization of a new Pseudomonas aeruginosa infection model using 2D airway organoids and dual RNA sequencing https://biorxiv.org/cgi/content/short/2023.03.11.532178v1 #biorxiv_micrbio
https://twitter.com/biorxiv_micrbio/status/1634785545350963202
"Perhaps this is as it should be: if Rupert Murdoch’s Wall Street Journal were going to embrace Free Market’s message enthusiastically, Soll would have had no reason to write the book."
https://lareviewofbooks.org/article/how-we-learned-to-love-free-markets/
Drug development sets its sights on ADAR
'RNA editing is rapidly gaining prominence as its transient and reversible changes promise a safer and more flexible option to reverse disease-causing mutations than DNA editing.'
“I couldn’t say that this specific pattern of binding, or this specific expression of genes, is a causal determinant in the patient’s response to immunotherapy,” he explains.
Bhattacharya was stymied by the age-old dictum that correlation does not equal causation — a fundamental stumbling block in artificial intelligence (AI).'
"The cheap servant
It is against the law for black servants to live under the same roof as their employers. In a private home, servants would have a separate little room in the backyard. She lives on the edge of opulence, while her own world is bare. Newspapers are her carpet, fruit crates her chairs and table."
fm 'Ernest Cole’s photographs of 1960s South Africa during apartheid' in the FT
https://www.ft.com/content/9919a741-9115-460c-b541-405b1ef2ab32
Thiago Carvalho
boosted
'TIR has previously provided a general summary of how to write scientific reports/papers, as well as more detailed and specific advice on writing Figure legends and Materials & Methods sections. Now we turn our attention to the real food & drink of any manuscript: the Results section.'
Thiago Carvalho
boosted
'We generated personalized libraries of neoantigen–HLA capture reagents to single-cell isolate the T cells and clone their T cell receptors (neoTCRs). Multiple T cells with different neoTCR sequences (T cell clonotypes) recognized a limited number of mutations in samples from seven patients with long-lasting clinical responses.'
"Our model is based on experimental measurements of neuronal and muscle activity and assumes gap junctional coupling among muscle cells and calcium-dependent force generation by muscles. With these assumptions, we can robustly reproduce a basic set of Hydra’s behaviors."
“A mi padre lo habían bajado al calabozo, pero a mi hermana la subieron a la secretaría y allí la violaron”, relató Josefina Lamberto a EL PAÍS en 2014, cuando viajó a Madrid desde Pamplona para sumarse, en el consulado argentino, a la causa abierta en Buenos Aires contra los crímenes del franquismo. Los vecinos habían escuchado los gritos de Maravillas, de 14 años. Unos campesinos la encontraron luego muerta, desnuda en un descampado. El cuerpo había sido atacado por los perros “y decidieron echar gasolina sobre los restos y quemarlos”
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
