Thiago Carvalho @cyrilpedia@qoto.org

Advice from David Tarlinton: read.

"One piece of advice that I did follow, although less and less as my time gets more and more allocated to other things, is to read. You have to read. You cannot be good at this without reading. And I understand just how much immunology has exploded in the last 10 years and the sheer range of things that just keep coming out as absolutely critical. But it's still important. And not just in the high-impact journals, because often what's in them is subject to all kinds of interpretations of what's fashionable. All the way down into the really solid journals, where there's still a great refereeing process and people are asking important questions and developing really solid answers. You just have to read."

https://onlinelibrary.wiley.com/doi/10.1111/imcb.12633#.ZBeBO9-ocxU.twitter

A very good movie, but if you've been waiting for Paul Schrader to make a comedy, be warned: this is not it.

"Colograph
The works presented here are created with alternative materials rather than etched on copper. From squashed paper costumes to packaging and leather book covers, objects are inked with different processes, both intaglio and planographic. Scales vary and are usually life-size." by @madparreira #Prints #Handmade #BookArt

https://madalenaparreira.com/Colographs#Printmaking

Job alert:

@EMBOPress is recruiting a scientific editor for The @embojournal

The deadline is tomorrow (Mar 21)

https://www.embl.org/jobs/position/EMBO00141

In my latest Clinical Pipeline column for Nature Medicine, a look at iPSC therapy for heart failure.

"Heartseed is not the only company currently performing clinical trials with iPSC-derived cardiomyocytes. Help Therapeutics in China is also using an approach with allogeneic iPSC-derived cardiomyocytes, and Göttingen University is running a trial for patients with end- stage heart failure using engineered heart muscle composed of a mixture of iPSC- derived cardiomyocytes and stromal cells."

https://www.nature.com/articles/d41591-023-00027-5

Add to this 400 (from a total 1450) state-sponsored PhD fellowships in this year's call.

"Serão estes sectores em Portugal tão mais inovadores do que os congéneres alemães? Não é provável. O mais plausível é que uma cegueira deliberada leve as autoridades portuguesas a tratar como I&D actividades que não o são verdadeiramente, empolando as estatísticas e concedendo incentivos fiscais e outros subsídios que em muitos casos não se justificam."

https://www.publico.pt/2023/03/20/economia/opiniao/fizeram-id-fetiche-2042985

"Due in part to the COVID-19 pandemic, the world has seen a worrying drop in immunization rates over the past few years, creating pockets of under-immunized communities at heightened risk of polio infection and paralysis. Children missing polio vaccinations creates opportunities for polio to re-emerge and spread – as seen in 2022 when WPV1 originating in Pakistan was detected in paralyzed children in Malawi and Mozambique."

https://speakingofmedicine.plos.org/2023/03/17/why-is-polio-making-a-comeback-and-what-can-we-do-about-it/

'We here demonstrate that mitochondrial DNA stress upregulates the immunoproteasome and MHC class I antigen presentation pathway via cGAS/STING/type I interferon signaling resulting in cell autonomous activation of CD8+ T cells.'
Wang et al @embojournal
#Immunology

https://www.embopress.org/doi/full/10.15252/embj.2022110597

'Thus, our results suggest that a heterochronic shift, involving enhanced Hox13 expression and BMP-signalling may have caused the reduction of the finfold size during the evolutionary transition from fish fins to tetrapod limbs.'

https://academic.oup.com/evolut/advance-article-abstract/doi/10.1093/evolut/qpad043/7073948?redirectedFrom=fulltext

Tools:

"This article presents an overview of the database with the most recent additions to Rat Genome Database's genome, variant and quantitative phenotype data."

https://academic.oup.com/genetics/advance-article-abstract/doi/10.1093/genetics/iyad042/7080056?redirectedFrom=fulltext