Thiago Carvalho @cyrilpedia@qoto.org

'The idea of cancer as predominantly a disease of old age is beginning to creak. An analysis last year showed that, in the G20 group of industrialised nations, rates of several cancers are rising faster among the young than among the old.'

https://www.ft.com/content/491d7760-c329-4f57-9509-0da36bc9e7de

Tools
"We developed a highly sensitive assay for detecting protein–protein interaction using chimeric receptors comprising two molecules of interest in the extracellular domain and interferon alpha and beta receptor subunit 1 or 2 (IFNAR1/2) in the intracellular domain."
#Immunology
https://www.pnas.org/doi/10.1073/pnas.2318190121

'After Covid-19 vaccines transitioned to the commercial market last fall, the Centers for Disease Control and Prevention stepped in to ensure that adults without insurance, or those whose insurance plans did not fully cover the vaccine, could receive shots for free. The agency’s Bridge Access Program provided roughly 1.5 million shots, said Dr. Georgina Peacock, the director of the immunization services division at the C.D.C. Nationwide, about 27 million adults do not have health insurance.

But the program ends this month, making it even harder for health centers to provide shots for free. The C.D.C. announced in May that funding for the program, which clinics expected to last through December, would actually run out by the end of August. A spokesman from the C.D.C. said the agency is discussing strategies to increase vaccine access for people without insurance.'
https://www.nytimes.com/2024/08/06/well/cdc-covid-vaccines-free-program.html

NOD news:
"Utilizing a Treg-centric screen, we show that intraislet Tregs have a uniquely dysfunctional phenotype, hallmarked by an almost complete lack of neuropilin-1 (Nrp1), a cell surface receptor required to maintain Treg stability."
#Immunology
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300216/267054/Regulatory-T-Cell-Insufficiency-in-Autoimmune?redirectedFrom=fulltext

Surprise du jour

"Google and Meta made a secret deal to target advertisements for Instagram to teenagers on YouTube, skirting the search company’s own rules for how minors are treated online."

https://www.ft.com/content/b3bb80f4-4e01-4ce6-8358-f4f8638790f8

'Times Square’s decline can be dated to the Depression, which introduced burlesque, flea circuses, and dime-a-dance halls, but it wasn’t until the 1970s that the bottom fell out. The grand Broadway palaces partitioned themselves into grindhouse theaters; Forty-Second Street became “the Deuce”; Strip-Tease gave way to Peep Show; Peep Show gave way to Live Sex. Still, it is possible to detect, in Friedman’s chronicles, beneath the squalor and disgust, contravening subtones of glee, ribaldry, even elation.'

https://www.criterion.com/current/posts/8549-how-the-movies-captured-times-square-s-grimy-golden-age

'Getting far less attention abroad, however, has been a flurry of activity inside Hungary targeting independent journalism and watchdog groups. At the centre of the crackdown is the country’s controversial new sovereignty protection office.

Led by a figure with close links to the ruling Fidesz party and granted the power to draw upon the intelligence services without judicial oversight, the office was set up by Orbán’s government, formally to monitor foreign influence.'

https://www.theguardian.com/world/article/2024/aug/06/somewhere-between-orwell-and-kafka-hungary-closes-in-on-its-media

'The CRUK CoL Centre Clinical Research Training Fellowship PhD Programme

Applications for CRUK CoL Centre Clinical Research Training Fellowships commencing in September 2025 are open.'

App. deadline 5 November 2024

https://www.colcc.ac.uk/crtf-recruitment-process/

'The analysis, published on Monday in The Annals of Internal Medicine and based on data for the year 2021, shows that cancer screening makes up a substantial proportion of what is spent every year on cancer in the United States, which most likely exceeds $250 billion. The researchers focused their estimate on breast, cervical, colorectal, lung and prostate cancers, and found that more than 88 percent of screening was paid for by private insurance and the rest mostly by government programs.'
https://www.nytimes.com/2024/08/05/health/cancer-screening-tests-cost.html

"This review discusses state-of-the-art techniques for the simultaneous profiling of multiple chromatin features in low-input samples and single cells, focusing on histone PTMs, DNA-binding, and chromatin proteins."

https://www.embopress.org/doi/full/10.1038/s44319-024-00199-2