Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'A key feature of the accelerated approval system is that manufacturers are required to conduct post-approval studies to demonstrate the drug’s therapeutic value. Among 93 cancer drug indications granted accelerated approval between 1992 and 2017, confirmatory trials reported an overall survival improvement in only 20% of them.'
'Discounts or rebates (a subcategory of so-called “managed entry agreements”) on drug prices are negotiated between governments and manufacturers, and a growing number are confidential.7 Confidential rebates are especially applied to cancer drugs.8 In consequence, countries using the external reference pricing system overestimate actual prices, triggering an upward spiral of drug prices.'
Thiago Carvalho
boosted
Postdoctoral Fellow
The de Cubas Lab in the Department of Microbiology & Immunology at the Medical University of South Carolina and the Hollings Cancer Center has an open
#ScienceJobs #job #CancerImmunology
Charleston #U...
https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-fellow/?feed_id=43710
'After a public dispute with NPR, which Twitter falsely labeled state-affiliated media, the platform last week removed all labels that had identified state-owned media, including those controlled by authoritarian states like Russia, China and Iran.'
https://www.nytimes.com/2023/04/26/technology/twitter-verification-problems.html
Thiago Carvalho
boosted
RT @NatMetabolism
Online now! Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction http://dlvr.it/Sn6VKR
Thiago Carvalho
boosted
New preprint from Geert Kops and co. on the role of CENP-E in building the kinetochore corona expansion. I've always been intrigued by the farnesyl (lipid) modification on CENP-E, identified years ago by Stephen Taylor's lab. This new preprint suggests that this modification and CENP-E have a structural (non-motor) role in stabilising corona expansion.
https://www.biorxiv.org/content/10.1101/2023.04.26.538394v1.full
Thiago Carvalho
boosted
"Transplantation of hNSCs has been shown to increase the number of CD4+CD25+Foxp3+ T regulatory cells (Tregs) in the spinal cords of murine models of MS, which is correlated with a strong localized remyelination response. However, the mechanisms by which hNSC transplantation leads to an increase in Tregs in the CNS remains unclear."
'In briefing documents published ahead an advisory committee meeting, FDA staffers argue that in metastatic castration-resistant prostate cancer (mCRPC), Lynparza has only showed a favorable benefit-risk profile in patients with BRCA mutations.'
Thiago Carvalho
boosted
Paired peripheral and central blood cultures are worth it!
#IDMastodon #MedMastodon #medicine #microbiology
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad225/7123639
Thiago Carvalho
boosted
@cyrilpedia Their observations show no change in the percentage of total #tumor associated #macrophages (TAMs) in the tumor tissue but a markedly increased percentage of NOS2+TAMs with no significant changes in arginase I expression...raising the question, which cell type would be the corresponding human counterpart? Macrophage or #monocyte ?
Thiago Carvalho
boosted
'Under pressure from their government, Chinese scientists have withheld data, withdrawn genetic sequences from public databases and altered crucial details in journal submissions. Western journal editors enabled those efforts by agreeing to those edits or withdrawing papers for murky reasons, a review by The Times of over a dozen retracted papers found.'
https://www.nytimes.com/2023/04/23/world/europe/chinese-censorship-covid.html
Thiago Carvalho
boosted
"Getting Franklin’s story right is crucial, because she has become a role model for women going into science. She was up against not just the routine sexism of the day, but also more subtle forms embedded in science — some of which are still present today."
Aquatint & chine-collé with colours added through viscosity printing by @madparreira
https://madalenaparreira.com/Aquatints
#Prints #Printmaking #Print #artofinstagram #Aquatint
#Handmade #chinecollé #artmastodon
'25 de Abril sempre, diz Rui Rocha. Mas que demonstra ele saber sobre o 25 de Abril? Nada. O povo quis uma sociedade nova e confrontou as classes dominantes – banqueiros, industriais e latifundiários – pondo em causa o seu domínio, poder e propriedade. Se recuasse no tempo, nesta luta, de que lado estaria Rui Rocha? Não é difícil de adivinhar: os interesses económicos que defende e apregoa estavam no lado do fascismo e do colonialismo, nunca no do povo.'
https://www.publico.pt/2023/04/26/opiniao/opiniao/rui-rocha-lugarcomum-2047426
Thiago Carvalho
boosted
'Dr. Franklin’s early death also meant she missed out on the Nobel Prize, but the Nobel Assembly could have found other ways to acknowledge her contribution, said Nils Hansson, a historian of medicine at Heinrich Heine University Düsseldorf, in Germany. Neither Dr. Watson nor Dr. Crick mentioned her when they accepted their awards, Dr. Hansson noted, although Dr. Wilkins, who also received the prize, did.'
https://www.nytimes.com/2023/04/25/science/rosalind-franklin-dna.html?
And a more recent piece by Asher Mullard for Nature
"A thumbs-up for tofersen from the US Food and Drug Administration would reinforce the agency’s shifting approach to neurological drugs."
Here's a link to the FDA's decision:
"FDA approved Qalsody (tofersen) to treat patients with amyotrophic lateral sclerosis (ALS) associated with a mutation in the superoxide dismutase 1 (SOD1) gene (SOD1-ALS)."
Thiago Carvalho
boosted
RT @physorg_com
#Geneticengineering provides new insights into preventing #malaria @BurnetInstitute @PLOSBiology https://doi.org/gr6jhx https://phys.org/news/2023-04-genetic-insights-malaria.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
