Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Research Associate / Postdoc - metabolic division of labour in ant colonies @social_fluids
Join us in #Cambridge as a #postdoc to study the #evolution of metabolic division of labour in superorganismal ant colonies! #bioinformatics #wetlab
Thiago Carvalho
boosted
RT @BetterScienceCH
At Swiss universities, 20-40% of researchers experience bullying, as recent reports show.
What to do when you are bullied: https://www.nature.com/articles/s41562-020-00937-1
How to be an anti-bullying-ally: https://www.science.org/doi/10.1126/science.abl7492#body-ref-R1
More on good team culture:
https://betterscience.ch/en/#/
Thiago Carvalho
boosted
RT @SwuliusLab
We’re excited to share cryo-TomoSim (aka CTS), our #cryoET modeling and simulation software, in addition to our new preprint documenting its use in training regressive denoising and semantic segmentation U-Nets.
Thiago Carvalho
boosted
'While in memory and innate cells the genes that encode untranslated mRNAs are linked to effector function, in B cells and the naïve T cell untranslated mRNAs are linked to activation, cellular resilience, anabolic processes and differentiation.'
Thiago Carvalho
boosted
Still going 12 billion miles from Earth!
“NASA is keeping Voyager 2 going until at least 2026 by tapping into backup power”
“The #Voyager 2, first launched in 1977, has been helping scientists investigate faraway planets and understand how the #heliosphere — the sun's outermost atmospheric bubble-like layer that traps particles and magnetic fields — protects #Earth from its volatile interstellar environment.”
#space #universe @NPR
https://www.npr.org/2023/04/30/1172921603/nasa-voyager-2-2026-backup-power-space
Thiago Carvalho
boosted
#Art
#ShodaKoho (庄田耕峯, ca. 1871-1946)
Moonlit sea
https://www.facebook.com/groups/256523979509585/permalink/782768860218425/
In this case, the 'in mice' tag may be a plus - getting a xenograft to take in immunocompetent hosts is a high bar.
'We report the editing of primary human islet cells to the hypoimmune HLA class I– and class II–negative and CD47-overexpressing phenotype and their reaggregation into human HIP pseudoislets (p-islets). Human HIP p-islets were shown to survive, engraft, and ameliorate diabetes in immunocompetent, allogeneic, diabetic humanized mice'
Thiago Carvalho
boosted
Gene Transfer in the Ocean
by Mechas
When it comes to generating variability in genes and functions, microbes are at the top of the list. Much of their genome plasticity and capacity to adapt to changing environments is driven by horizontal gene transfer (HGT), the acquisition of genetic information from other cells rather than from vertical inheritance upon division.
Read more → https://schaechter.asmblog.org/schaechter/2023/05/gene-transfer-in-the-ocean.html
'In any case, it is remarkable that senolysis of a small fraction of senescent osteocytes may account for the robust bone-protective effect, further supporting the importance of osteocytes for bone metabolism and skeletal health. Given their crucial role in orchestrating bone remodeling and their high degree of connection, these few senescent osteocytes may be sufficient to cause functional chaos through cellular miscommunication.'
"Some 30 organizations and 3 members of the European Parliament co-signed a statement to the European Commission, presented in Luxembourg on 19 April, calling for it to name racism as a health determinant in legislative and policy documents."
Thiago Carvalho
boosted
An interesting look at the research and research management culture at Bell Labs (via The Browser).
"Over the years, Bell Labs management developed a small but coherent set of constraints and rules of thumb to ensure that its researchers internalized that, as Jim Fisk put it, it was “a matter of individual responsibility” to choose the right problems and that Bell Lab’s success in doing this at scale, across thousands of individuals, was “essentially automatic.”"
https://freaktakes.substack.com/p/how-did-places-like-bell-labs-know?ref=thebrowser.com
The leading compound in Iveric's pipeline is a a C5 inhibitor for geographic atrophy.
'Astellas Pharma agreed to buy US biotech group Iveric Bio for roughly $5.9bn, marking the Japanese drugmaker’s largest-ever acquisition and giving it access to the rapidly expanding market for age-related eye diseases.'
https://www.ft.com/content/fa8b17e0-ea52-4450-8218-d721f76c6d9e
Thiago Carvalho
boosted
In fact, the next pandemic has already begun.
To appreciate this catastrophe, we’ve got to move the focus off humans, at least for a bit.
#H5N1 is devastating the world’s birds. Eagles are dropping dead, as are great horned owls and peregrine falcons and pelicans. Twenty California condors recently died of what’s suspected to be avian flu — 10 are confirmed so far. It’s the worst thing that has happened to wild birds since the pesticide DDT.
Thiago Carvalho
boosted
Today's entry in #OneThousandYearsOfWomen is Christine de Pizan, the first professional female writer in Europe, and it's going to be very brief because the biography I found was very brief, and also she was born in 1364 and we don't have tons of sources about her. It is a mark of how special she was that we know anything about her at all, in fact.
'Fixing democracy will require a myriad of reforms. Just in the United States, this includes preventing gerrymandering, getting rid of the filibuster, guaranteeing voting rights, and constraining the power of an anti-democratic Supreme Court. But to ensure that such reforms add up to a healthier and more sustainable form of democracy, we need something more. Instead of democratic triumphalism, we need to understand when collective decision-making works well and when it works badly.'
https://democracyjournal.org/magazine/68/the-new-libertarian-elitists/
Thiago Carvalho
boosted
Updating this! Would appreciate a boost!
Lost my job recently and it's been rough out there. I'm a podcast editor, sound designer, and VA trying to build my portfolio. Let me craft your fiction or nonfiction audio into its best shape. I'd love to try my hand at a TTRPG! I can also edit videos.
I've written and directed for the award-winning audio drama Someone Dies In This Elevator and have my own in the works.
3 free gigs are left available! https://ryanjameshorner.com/
Investigational lupus therapies: another one bites the dust, in this case Amgen's bispecific targeting ICOSL/BAFF (rozibafusp alfa/AMG 570 in a phase 2b study).
https://www.fiercebiotech.com/biotech/amgen-discontinues-rd-work-lupus-futility-reasons
“Pay for grad students hasn’t increased in 20 years, while there has been 50% inflation over the same period,” says Sarah Laframboise, a biochemistry PhD student at the University of Ottawa and executive director of Support Our Science, a student-led campaign group that is organizing the walkout.'
Thiago Carvalho
boosted
RT @NatureMedicine
#Malaria is increasing in Indigenous and artisanal mining areas in the Brazilian Amazon, impacting the Yanomami people.
Correspondence from @marciacastrorj @HarvardChanSPH and Cassio Peterka, Ministry of Health, Brazil
#WorldMalariaDay
https://www.nature.com/articles/s41591-023-02280-0
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
