Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
‘Labour warns’ in the headline is what makes it art:
"Some NHS staff need to “get over cultural sniffiness” about profit motives to work with pharmaceutical and tech companies to reverse the steep drop in UK clinical trials, shadow health secretary Wes Streeting has said."
https://www.ft.com/content/801fa00e-335c-4b54-b507-4d4b497f73e0
'And as other tracking efforts wind down, some communities are racing to set up wastewater surveillance programs for the first time, Dr. Kirby noted. “This is actually driving more interest in wastewater,” she said.'
Thiago Carvalho
boosted
If you don't know what the Human Pangenome is and why it's important, I've reviewed it here
https://erictopol.substack.com/p/pearls-from-the-pangenome
'I said, “I’m not really sure I want to do a cop show.” And Levinson said: “This is about the homicide detectives. They’re thinking cops. There’s no gun battles, there’s no car chases.” And I said: “That’s impossible. I’ll do it.”
Racial differences in edication for Opioid Use Disorder (OUD)
'In the 180 days after the index event, patients received buprenorphine after 12.7% of events among Black patients, after 18.7% of those among Hispanic patients, and after 23.3% of those among White patients; patients received naloxone after 14.4%, 20.7%, and 22.9%, respectively; and patients received benzodiazepines after 23.4%, 29.6%, and 37.1%, respectively.'
https://www.nejm.org/doi/full/10.1056/NEJMsa2212412?query=featured_home
Thiago Carvalho
boosted
It's out! We asked what triggers neurite regrowth after pruning in fly sensory neurons, and how: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010526
Thiago Carvalho
boosted
Deforestation in Brazilian Amazon Fell 68% in April 2023.
"Still a lot more to do but this is the impact of electing an environmentalist like Lula over a right-wing populist like Bolsonaro," said one observer.
Deforestation in Brazil's Amazon rainforest decreased compared with last year, according to preliminary government data published Friday.
The finding reflects positively on the administration of leftist Brazilian President Luiz Inácio Lula da Silva, who has vowed to make the destruction of the crucial ecosystem "a thing of the past."
#climate #climatechange #climatecrisis #brazil
https://www.commondreams.org/news/brazil-amazon-deforestation-down-68-april-2023
'These results indicate that NRF2 regulates cardiac metabolic reprogramming by stimulating the diversion of glucose into the PPP, thereby providing cardiac protection during stress by generating NADPH and providing nucleotides to prevent stress-induced DNA damage.'
#Preprint
https://www.biorxiv.org/content/10.1101/2023.05.12.540342v1?med=mas
Obesity and #covid19 vaccination.
"Here we focus on individuals with severe obesity (those at highest risk). We conducted a prospective, longitudinal study that allowed us to demonstrate that, although initial and peak responses were similar in individuals with severe obesity and individuals with normal weight, there was accelerated decline in antibody levels over time that correlated with increased frequency of hospitalization and mortality from breakthrough infections."
Thiago Carvalho
boosted
Molecular atlas for Crohn's disease & ulcerative colitis in patients receiving anti-TNF.
'We describe a therapeutic atlas for Crohn's disease (CD) and ulcerative colitis (UC) following anti-tumour necrosis factor (TNF) therapy. We generated ~1 million single-cell transcriptomes, organised into 109 cell states, from 216 gut biopsies from 38 patients and three controls, revealing disease- and therapy-specific differences.'
#Preprint #IBD #ulcerativecolitis #crohnsdisease #immunology #TNF #immunotherapy #mucosalimmunology
'Juba’s scientific contributions are his greatest legacy to the modern world. He is not only our best witness to that now-extinct elephant; drawing on his doctor’s name (Antonius Euphorbus), he christened the group of plants still known as Euphorbia (the red-leaved poinsettia is the most easily recognized of these), which was discovered on one of his expeditions into the Atlas Mountains. Chances are he’s behind the name of the Canary Islands too, taken from the big dogs (canes, in Latin) found on one of his expeditions there.'
Thiago Carvalho
boosted
'The ‘continuous urge to win the battle’ may extend to physicians, they noted. Oncologists’ desire for ‘victory’ over cancer may be detrimental to their patients if they’re inclined to prescribe inappropriately aggressive treatments. And patients, wishing to ‘beat’ cancer, may be reluctant to accept palliative or hospice care.'
https://aeon.co/essays/should-we-abandon-the-idea-that-cancer-is-something-to-fight
Thiago Carvalho
boosted
For anyone interested in using our LIPSTIC (CD40 and universal) or K-tag mice, they are now available for registering interest at Jax.
https://mice.jax.org/?sharedlink=1&c&term=victora&sortbyname=Most%20Relevant
Thiago Carvalho
boosted
JOB AD: the Centre for Culture and Evolution is hiring a new Director!! Reader/Prof
The CCE is a unicorn of a Centre, with ~15 full time staff. Lots of disciplines represented: cultural evolution, ev psych, human behavioral ecology. We have it all: field work, modelling, boring online surveys (me). Research themes: Gender & Sexuality; Religion; Cooperation & Conflict; Learning & Development; Digital Living; Cultural Identities & Immigration.
Please boost & ask any ?s
https://www.jobs.ac.uk/job/CZS909/professor-reader-in-psychology-11022
Thiago Carvalho
boosted
"The model was trained on only a few thousand antibody sequences, out of the nearly 100 million protein sequences it learnt from. Despite this, a surprisingly high proportion of the model’s suggestions boosted the ability of antibodies against SARS-CoV-2, ebolavirus and influenza to bind to their targets."
Thiago Carvalho
boosted
"It is conceivable that, although extensive genetic and epigenetic evolution occurs within cancer models, such evolution might not translate into biologically meaningful cellular properties. That is, this phenomenon could represent a molecular curiosity with little practical implication. Unfortunately, this does not seem to be the case. Genomic changes that arise throughout model propagation have been associated with marked phenotypic changes across all cancer model types"
Thiago Carvalho
boosted
Thiago Carvalho
boosted
'Schools have also been targeted, with right-wing pressure groups such as ‘Moms for Liberty’ recognising no irony as they oppose the freedom to read, through controlling which books are stocked in classrooms or school libraries. One of the books the group sought to ban in Tennessee was Ruby Bridges Goes to School, which celebrates racial integration in schools.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
