Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
'Poland, historically staunchly Catholic, has slowly been coming to terms with the scale of historical sexual abuse in the church, but until recently the figure of John Paul II, whom many Poles revere for his role in the ending of communist rule in the country, has remained untouchable.'
Thiago Carvalho
boosted
A famous #Polycomb protein with roles in gene silencing but also activation!
BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate
Front. Cell Dev. Biol., Volume 11 - 2023
'Because semiautomatic weapons are illegal in Serbia, the state was able to respond quickly. The authorities did make some early blunders. Education Minister Branko Ružić traced the causes of the shootings to “video games” and “so-called Western values,” and was compelled to resign within four days. Police requested that schools in Kikinda and Užice deliver lists of “problematic and asocial” children (a request the schools rightly refused). But it took only a day for President Aleksander Vučić to deliver a speech promising swift action to protect public safety and to reduce ownership of illegal firearms by 90 percent.'
'In this trial involving children 1 to 3 years of age with peanut allergy, epicutaneous immunotherapy for 12 months was superior to placebo in desensitizing children to peanuts and increasing the peanut dose that triggered allergic symptoms.'
https://www.nejm.org/doi/full/10.1056/NEJMoa2212895?query=featured_home
'Oxford university ended its relationship with the Sacklers on Monday after a Financial Times investigation into its continued ties with the wealthy family led academics and students to call for sweeping reforms.'
https://www.ft.com/content/28ea87bb-f873-4693-a767-5dc79c5b3b92
'The task force acknowledged that dense breasts can increase a woman’s risk of breast cancer and that certain race or ethnicity groups are at higher risk for early-onset breast cancer. But it failed to issue more individualized recommendations for these groups, instead calling only for more research. Black women under 50, for example, die of breast cancer at twice the rate of white women under 50 in the United States. We have known this for decades, and it is unacceptable.'
#BreastCancer
https://www.nytimes.com/2023/05/16/opinion/breast-cancer-screening.html
Thiago Carvalho
boosted
Last chance to register for the ICOR webinar where you can learn about updates on collaborative open research initiatives:
✳️an update from the eLife on their new publishing model,
✳️a report on the Gates Foundation study on fair and equitable pricing for publishing,
✳️an overview from the Pew Charitable Trusts' Evidence Project,
& more
Join ICOR tomorrow 10:30am – 12pm ET
https://us02web.zoom.us/meeting/register/tZItcO2qrj4oEtfk_CFus4rYIqX0awNwh0pk#/registration
Thiago Carvalho
boosted
EXO1 to the rescue: How does #EXO1 save #BRCA1-deficient cells?
The team of Profs. H. van Attikum & S.M. Noordermeer shows that BRCA1-deficient cells are unable to overcome damage if EXO1 is deleted. #preprint
#preLight by Jennifer Ann Black: https://prelights.biologists.com/highlights/exo1-mediated-dna-repair-by-single-strand-annealing-is-essential-for-brca1-deficient-cells/
Thiago Carvalho
boosted
"A monolithic group of scientists will bring many of the same preconceived notions to their work. But a group of many backgrounds will bring different points of view that decrease the chance that one prevailing set of views will bias the outcome. This means that scientific consensus can be reached faster and with greater reliability. It also means that the applications and implications will be more just for all. How is this a threat to scientific rigor and the merit of discoveries?"
https://www.science.org/content/blog-post/it-matters-who-does-science#.ZF4ty3LYhwN.twitter
Thiago Carvalho
boosted
'These results indicate that NRF2 regulates cardiac metabolic reprogramming by stimulating the diversion of glucose into the PPP, thereby providing cardiac protection during stress by generating NADPH and providing nucleotides to prevent stress-induced DNA damage.'
#Preprint
https://www.biorxiv.org/content/10.1101/2023.05.12.540342v1?med=mas
Thiago Carvalho
boosted
Thiago Carvalho
boosted
People seem to believe that Omicron is milder or that people have protection from prior infections, but a new study suggests children's risk of #LongCOVID is not reduced with reinfections. “12-16% infected with Omicron met the research definition of long COVID at 3 and 6 months after infection, with no evidence of difference between cases of first-positive and reinfection... substantial numbers of CYP (children & young people) are likely to be impacted.”
https://www.jpeds.com/article/S0022-3476(23)00311-6/fulltext
"A monolithic group of scientists will bring many of the same preconceived notions to their work. But a group of many backgrounds will bring different points of view that decrease the chance that one prevailing set of views will bias the outcome. This means that scientific consensus can be reached faster and with greater reliability. It also means that the applications and implications will be more just for all. How is this a threat to scientific rigor and the merit of discoveries?"
https://www.science.org/content/blog-post/it-matters-who-does-science#.ZF4ty3LYhwN.twitter
'I don’t know if you’ve ever been to a zoning-board meeting where folks are debating affordable housing. It shows you just how much work and effort and force goes into defending segregation. The folks who show up for those meetings are really not representative of the broader community. They tend to be whiter, more affluent, more likely to be homeowners. It’s this interesting thing wherein a democratic process has an undemocratic outcome, because representation in this case is a defense of the status quo.'
Thiago Carvalho
boosted
'Juba’s scientific contributions are his greatest legacy to the modern world. He is not only our best witness to that now-extinct elephant; drawing on his doctor’s name (Antonius Euphorbus), he christened the group of plants still known as Euphorbia (the red-leaved poinsettia is the most easily recognized of these), which was discovered on one of his expeditions into the Atlas Mountains. Chances are he’s behind the name of the Canary Islands too, taken from the big dogs (canes, in Latin) found on one of his expeditions there.'
Thiago Carvalho
boosted
Obesity and #covid19 vaccination.
"Here we focus on individuals with severe obesity (those at highest risk). We conducted a prospective, longitudinal study that allowed us to demonstrate that, although initial and peak responses were similar in individuals with severe obesity and individuals with normal weight, there was accelerated decline in antibody levels over time that correlated with increased frequency of hospitalization and mortality from breakthrough infections."
Thiago Carvalho
boosted
🦠 Although #CellDeath is essential for defense against viral infections, it can also lead to severe disease. Manolis Pasparakis @UniCologne explains more
👉 https://bit.ly/42jdlHS
@HorizonMagEU @CECAD_ @UniCologne_D7
#inflammatorydiseases #immunology https://www.youtube.com/shorts/q2UtCbyhWUg
🐦🔗: https://n.respublicae.eu/ERC_Research/status/1658004326172991488
Thiago Carvalho
boosted
PRO-Simat: Protein network simulation and design tool | https://www.sciencedirect.com/science/article/pii/S2001037023001757?via%3Dihub #proteomics
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
