Thiago Carvalho @cyrilpedia@qoto.org

Noisy ageing (#preprint).

"Through analysis of mouse single-cell transcriptome data across diverse organs and ages, we find that cellular age explains a large proportion of the variation in the age-related increase in transcriptome variance."

https://www.biorxiv.org/content/10.1101/2023.05.31.543091v1?med=mas

Rare #cancer treated with #Immunotherapy : new data for #sarcoma subtype angiosarcoma, treated with double #checkpointinhibitors and showing clinical effects. But we still need better #biomarkers for #precisionmedicine in #immunology ... @chfloudas @cyrilpedia
https://jitc.bmj.com/content/9/8/e002990

The AHA is pleased to announce the Fellowships in Aerospace History: Andrew Ross (Georgetown Univ.), Haris Durrani (Princeton Univ.), and William Marino (Univ. of California, Santa Barbara). #AHAPerspectives https://www.historians.org/research-and-publications/perspectives-on-history/summer-2023/announcing-the-2023%E2%80%9324-nasa-fellows

Hello #ECRs! Don't forget to register!
White House Listening Session on: #OpenScience Possibilities for Career Advancement: Perspectives from Early Career Researchers on Opportunities and Challenges in Career Progression and Trajectory

⏰ It's tomorrow!
https://buff.ly/3pYMceZ

Está no ar o Nr. 7 da #Almanaque. Agora bimestral.
Viva Junho, a Feira do Livro e a festa estival,
farturas, copos de vinho, fino ou imperial,
vivam os amigos e o verão, a pândega em geral!
🎉
Ilustração minha em homenagem a isso tudo, e à Manu e ao Emanuel, em particular 🙂
#ilustração #illustration #editorial #editorialillustration #coverillustration #magazinecover #magazinecoverillustration
#liaferreira #ilustracion #ilustration #almanaquemag #almanaquemagazine #revistaalmanaque #festas

Predatory journal spam: have you noticed that the messages target a specific article you wrote in the past? For the last few days, about half of the messages I get from "different” senders mention a 2016 paper from my lab. I guess it suggests the messages are linked, because it's a bit unlikely otherwise.

#PredatoryJournals #AcademicSpam #GreetingsForTheDay

More detailed histories of #libraries and #information #infrastructure please. “In this way, SUPARS is meaningful as both a design far ahead of its time and as a counterexample to established techno-utopian histories of the internet and the world wide web.” https://aeon.co/essays/the-1970s-librarians-who-revolutionised-the-challenge-of-search

Haymar Wint, Kohji Takei, Tetsuya Takeda and colleagues discover that pacsin-2 plays an essential role in collective cell migration of cancer cells by regulating endocytosis of N-cadherin.
#OpenAccess

https://journals.biologists.com/jcs/article/136/10/jcs260827/310877/Pacsin-2-dependent-N-cadherin-internalization

Haymar Wint shares the story behind this research in our ‘First person’ interview: https://journals.biologists.com/jcs/article/136/10/jcs261309/310873/First-person-Haymar-Wint

This article is a @ReviewCommons transfer.
You can find out more about the transfer to affiliate journals including @J_Cell_Sci here: https://www.reviewcommons.org/authors/

Bioinformatician with PhD and experience in immunology and single-cell

Institut Curie

Looking for a #bioinformatician with a PhD, experience in #immunology and #single-cell. Come join us at #InstitutCurie in #Paris

See the full job description on jobRxiv: https://jobrxiv.org/job/institut-curie-27778-bioinformatician-with-phd-and-experience-in-immunology-and-si...
https://jobrxiv.org/job/institut-curie-27778-bioinformatician-with-phd-and-experience-in-immunology-and-single-cell/?feed_id=47187

📢New on the Node

In this blog post, our correspondent
Dina Myasnikova talks about her experience as a women researcher in Japan, and how she found support from like-minded people by joining 'Women in Science Japan':

https://thenode.biologists.com/you-are-not-alone/discussion/

#theNodeCorrespondents #WomenInSTEM

"Our investigation reveals that the fetal HSCs respond to T. gondii infection with virulence-dependent changes in proliferation, self-renewal potential, and lineage output. Furthermore, maternal IFNγ crosses the fetal–maternal interface, where it is perceived by fetal HSCs."

#Immunology #Interferon #Toxoplasma

https://www.embopress.org/doi/full/10.15252/embj.2022112693

Issue 10 is now complete!

On the cover: newly differentiated fat bodies (green) with lipid droplets (magenta) in the abdomen of a pharate adult fly. See Research article by Tsuyama et al: https://journals.biologists.com/dev/article/150/10/dev200815/310416/Dynamic-de-novo-adipose-tissue-development-during

Also in Issue 10:
▪5 Research Highlights on DH31, Hobx, Shrub, EIF4A3 & morphogen gradients
▪Juan Modolell Obituary
▪Author interview with Zainab Afzal & Robb Krumlauf
▪Brain development & neurodegeneration Spotlight
▪Human embryo implantation Review

https://journals.biologists.com/dev/issue/150/10

'Meanwhile, a large cache of gene variants thought to be unique to humans, because they are found in Homo sapiens but not in the archaic human relatives called Neanderthals and Denisovans, has turned out to be widespread across primates. Almost two-thirds of the variants thought to be solely human were present in at least one other primate species, and more than half were found in two or more.'

https://www.nature.com/articles/d41586-023-01776-6

Adam Mastroianni discusses the stifling of science innovation by treating it as a "weak-link problem" (here: https://www.experimental-history.com/p/science-is-a-strong-link-problem).

In the same way... I just wonder whether we're missing a drive to find real, innovative solutions because we're so worried about only reaching for answers we are allowed to think about.

9/n #AcademicChatter