Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Boehringer moves forward with its glucagon/GLP-1 receptor dual agonist, survodutide.
"The German drugmaker is now preparing to launch a late-stage trial of its drug, which if approved, would compete with Eli Lilly’s Mounjaro and Novo Nordisk’s Wegovy. US pharma group Pfizer and biotech Regeneron are among the others hoping to enter the market."
#Metabolism #Pharma #DrugDevelopment #DrugDiscovery #Obesity
https://www.ft.com/content/d3f5e936-05af-4775-8247-cff1c007ba45
'Nos últimos 17 anos, Portugal enviou 309,6 milhões de euros para Universidade Carnegie Mellon, o Instituto de Tecnologia do Massachusetts (MIT) e a Universidade do Texas em Austin, contou António Sousa Pereira, explicando que as transferências se inserem numa parceria lançada entre 2006 e 2007, através da Fundação para a Ciência e a Tecnologia (FCT).'
Thiago Carvalho
boosted
"On being asked what made the LMB such a remarkable place, Max answered: ‘Creativity in science, as in art [referring to the Renaissance in Florence], cannot be organised. It arises spontaneously from individual talent. Well-run laboratories can foster it, but hierarchical organisations, inflexible bureaucratic rules, and mountains of futile paperwork can kill it. Discoveries cannot be planned, they pop up, like Puck, in unexpected corners.’"
From Daniela Rhodes' 2002 piece on #MaxPerutz
https://www.embopress.org/doi/full/10.1093/embo-reports/kvf103
Thiago Carvalho
boosted
Local enhancers of the #PAIR4 regulatory module promote distal V-H gene #recombination at the #Igh locus and contribute to #Bcell receptor repertoire diversification
Louisa Hil et al Busslinger lab @IMPvienna
Targeting FGF21 and GLP-1 pathways in NASH. My latest Clinical Pipeline column for Nature Medicine is online.
#drugdiscovery #drugdevelopment #metabolism #LiverDisease #FattyLiver #SciComm
A light sentence, but better than nothing.
"Surgeon Paolo Macchiarini, who was once hailed as a pioneer of stem cell medicine, was found guilty of gross assault against three of his patients today and sentenced to 2 years and 6 months in prison by an appeals court in Stockholm."
Thiago Carvalho
boosted
The depths to which Didier Raoult dived early on:
"the Marseille facility had conducted unauthorized clinical trials on the diagnosis of tuberculosis (Mycobac trial). Some of the patients enrolled in this trial received in-house treatment, a protocol that did not comply with international recommendations for the treatment of this disease."
https://www.lepoint.fr/sante/didier-raoult-30-years-of-unregulated-experiments-on-human-22-06-2023-2525726_40.php
George and the FT might be hearing from The Onion's legal team soon.
https://www.ft.com/content/05808970-09a0-4f86-af23-4f05db627742
'Here, we aimed to understand how closely related strains with overlapping metabolic capacities can co-bloom (i.e., both strains reaching high densities) in the mammalian gut and how this promotes the spread of antibiotic resistance plasmids.'
#HostPathogen #microbiology #mucosalimmunology
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00222-6
Thiago Carvalho
boosted
Damaged neurons repair #axons, but it wasn't clear whether the axons of damaged ciliated #neurons in #insects could also recover. Melissa Rolls & colleagues have discovered that insect ciliated neurons do recover, even if the axon is severed close to the cell body, and they use the same mechanism for recovery as conventional neurons
#neuroethology #zoology #entomology #biology
https://journals.biologists.com/jeb/article/226/12/jeb246176/318020
To read the full research go to https://journals.biologists.com/jeb/article/226/12/jeb245717/318059
Thiago Carvalho
boosted
On this day in 1903: George MacDonald born, worked out transmission of vector-born diseases like malaria #ThisDayInBiotech
Thiago Carvalho
boosted
Targeting FGF21 & GLP-1 pathways in NASH. My latest Clinical Pipeline column for Nature Medicine is online.
#drugdiscovery #drugdevelopment #metabolism #LiverDisease #fattyliver
Thiago Carvalho
boosted
Academic hyperbole:
When did "cutting edge" become "bleeding edge”? Why is “state-of-the-art” no longer sufficient so that we must now be working “beyond state-of-the-art”. Don’t forget that we can no longer be "world leading”, we must be "world beating”. Makes me wonder what's next?
On finding a home for your blog/newsletter:
"My reasons for wanting out are explained here. The bottom line, though, is that I just wasn’t comfortable on a platform that’s a major leagues money-maker for the misinformation-hate complex. And I didn’t want to wait for the likely-inevitable enshittification development or event that made moving urgent. Migrating slowly, while my newsletter and its footprint are still small, had to be easier."
"In fact, teleosts show a tremendous variety of adaptive behaviors similar to birds and mammals, however, the neural basis mediating these behaviors remains elusive. We performed a systematic comparative survey of the goldfish telencephalon; the seat of plastic behavior, learning and memory in vertebrates."
#Preprint #Evolution #neuroscience
https://www.biorxiv.org/content/10.1101/2023.06.19.545605v1?med=mas
Thiago Carvalho
boosted
Poverty kills. Yet, we remain silent about it's deadly effects. https://www.theguardian.com/commentisfree/2023/jun/22/us-leading-cause-death-poverty-crisis
Thiago Carvalho
boosted
RT @: (BioRxiv All) Target-decoy false discovery rate estimation using Crema (RSS) #BioRxiv #MassSpecRSS
Thiago Carvalho
boosted
Research Technician, Mouse Colony - Cheadle Lab
Cold Spring Harbor Laboratory
See the full job description on jobRxiv: https://jobrxiv.org/job/research-technician-mouse-colony-cheadle-lab/?feed_id=48229
#ScienceJobs #hiring #research
Cold Spring Harbor #UnitedStatesUS #ResearchTechnician
https://jobrxiv.org/job/research-technician-mouse-colony-cheadle-lab/?feed_id=48229
Thiago Carvalho
boosted
There's more to gasdermin than just proptosis.
'Our study supports that differential cleavage of GSDMD can be understood as a regulatory hub controlling immunity versus tolerance in the small intestine.'
#Immunology #mucosalimmunology
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
