Thiago Carvalho @cyrilpedia@qoto.org

'Há, no entanto, em especial, um grupo que escapou à penalização do seu papel na ditadura: os juízes dos Tribunais Plenários. Esses juízes eram serventuários da PIDE, exactamente serventuários, impediam qualquer simulacro de julgamento e de lei'

https://www.publico.pt/2024/06/22/opiniao/opiniao/justos-avancam-ofensiva-politica-impuros-2094868

'The book is also something of a diptych. The resonances between the two greatest public-health crises of Fauci’s tenure at niaid are impossible to ignore. Both cases involve asymptomatic infection, a scramble for tests and treatments, public-information campaigns, and the search for a vaccine—miraculously fast for covid-19, still unfulfilled for H.I.V. '
https://www.newyorker.com/magazine/2024/06/24/on-call-a-doctors-journey-in-public-service-anthony-fauci-book-review

'Patients with liver metastases derive limited benefit from immunotherapy independent of other established biomarkers of response. In multiple mouse models, we show that liver metastases siphon activated CD8+ T cells from systemic circulation. Within the liver, activated antigen-specific Fas+CD8+ T cells undergo apoptosis following their interaction with FasL+CD11b+F4/80+ monocyte-derived macrophages.'
#Immunology
https://www.nature.com/articles/s41591-020-1131-x

Tasty, but often lacking in nutritional value:
"First, there is Causal Salad: You put everything into a regression equation, toss with some creative story-telling, and hope the reviewers eat it. In general, this is not a valid approach, for well-known reasons. But it can get you published. Causal salad can discover causes too. But you have to get lucky. The Salad isn’t only regression. Really any procedure that hopes to take a list of variables (features) and return causal inference is Causal Salad. No amount of data reliably turns salad into sense."
https://elevanth.org/blog/2021/06/15/regression-fire-and-dangerous-things-1-3/

'We find that diapause evolved by a recent remodeling of regulatory elements at very ancient gene duplicates (paralogs) present in all vertebrates. CRISPR-Cas9-based perturbations identify the transcription factors REST/NRSF and FOXOs as critical for the diapause gene expression program, including genes involved in lipid metabolism.'

https://www.cell.com/cell/fulltext/S0092-8674(24)00474-4

'De pouquíssimos intelectuais públicos se pode dizer que estão em condições de comemorar em vida os 85 anos do seu primeiro artigo político. Mas é o caso de Chomsky: foi em 1939, tinha ele dez anos, que publicou um primeiro artigo político no jornal da sua escola, em Filadélfia, sobre a Guerra Civil de Espanha.'
@ruitavares
https://expresso.pt/opiniao/2024-06-20-a-semana-em-que-chomsky-nao-morreu-2f332ce5

"Among the 247,854 COVID-19-related papers published in PubMed, 12,152 were initially released as preprints and were eventually published in 1,380 journals. This number is more than five times the 246 journals to which submissions can be made directly from bioRxiv through the B2J program. Journals with higher impact factors and Normalized Eigenfactor scores tend to publish a larger number of preprint-derived articles"
https://www.biorxiv.org/content/10.1101/2024.05.28.596359v1

'Using a version of OpenAI’s GPT-4 program through Microsoft’s Azure cloud service, the researchers found that a tailored generative AI application was able to quickly comb through patient notes within electronic medical records and accurately identify those with heart failure who met the criteria for a study.'
https://www.fiercebiotech.com/medtech/study-shows-generative-ai-can-speed-clinical-trial-enrollment-pennies-patient