Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis https://www.biorxiv.org/content/10.1101/2024.07.09.602728v1?med=mas
'Far from the Bastille, at the Clark Art Institute in the Berkshires, one of the most remarkable exhibitions I’ve seen in years punches right at the heart of today’s altercations over nationality and democracy, culture and politics, and what it means to be a citizen. Guillaume Lethière (1760—1832) was a Neoclassical painter of mixed race who has never, until now, been the subject of a solo museum show. Born in the French Caribbean, almost certainly into slavery, he reached the summits of artistic achievement in Paris and Rome. As rebellions and revolutions shook both France and the Caribbean, he painted massive history paintings of heroes in togas, and portraits of men and women from Europe and the Antilles. It was Lethière’s calling, in an era where no bonds seemed stable, to give form to fraternité.'
https://www.nytimes.com/2024/07/11/arts/design/guillaume-lethiere-clark-louvre-painter.html
Wilson Didn't Resign. The World Suffered. Biden Need Not Repeat That Mistake
Mechanism of membrane curvature generation and caveola formation by flat disc-like complexes of caveolin https://www.biorxiv.org/content/10.1101/2024.07.09.602763v1?med=mas
STAT+: The biggest misconception about CTE, according to a leading brain trauma expert
'All in all, polygenism has been hugely influential in American scientific racism and its fallout. Indeed, you cannot fully understand American racism without understanding polygenism and its history. So how did polygenism first gain traction? And how did it become a mainstream view among the American scientific establishment?'
https://aeon.co/essays/modern-racism-rests-on-scientific-theories-from-the-19th-century
CAR-T therapy's complications, as well as its benefits, become clearer in 'flurry' of cancer studies
https://www.statnews.com/2024/07/12/cancer-car-t-therapy-fda-secondary-cancers/?utm_campaign=rss
'Studies suggest that the virus is spreading between cows through contaminated milking equipment, rather than airborne particles. The biggest risk is that it could evolve to infect mammals more effectively, including through the respiratory system, which would make it more difficult to contain. Given the close and regular contact that cows have with people, airborne transmission could spark a pandemic'
https://www.nature.com/articles/d41586-024-02237-4
Just spotted that the new Govt. has withdrawn from defending the decision of the previous Govt. to grant permission for the development of a new coal mine in Cumbria, which reaches the high court next week.
Offering no defence (due to the recent recognition by the housing department of an 'error in law') the appeal against the decision to go ahead will succeed & the coal mine will be no more.
For those wondering about Keir Starmer's green credentials, this looks like a good first step.
'Pfizer is planning to test a daily weight-loss pill in mid-stage trials later this year, as the struggling pharmaceutical group pins its hope on the experimental drug as its route into a market projected to be worth more than $130bn a year.'
https://www.ft.com/content/865f8432-6c88-40ca-a48e-06b30a81f176
Joan Didion, 1988
'When we talk about the process, then, we are talking, increasingly, not about “the democratic process,” or the general mechanism affording the citizens of a state a voice in its affairs, but the reverse: a mechanism seen as so specialized that access to it is correctly limited to its own professionals, to those who manage policy and those who report on it, to those who run the polls and those who quote them, to those who ask and those who answer the questions on the Sunday shows, to the media consultants, to the columnists, to the issues advisers, to those who give the off-the-record breakfasts and to those who attend them; to that handful of insiders who invent, year in and year out, the narrative of public life.'
https://www.nybooks.com/articles/1988/10/27/insider-baseball/
Behold!
'The mayor wheeled the new NYC Bin down Gracie Mansion’s driveway and, with his characteristic swagger, demonstrated how the innovative new technology works: you open the lid and you put the rubbish in. It’s highly intuitive technology.'
'However, we found through a chance encounter that some unscrupulous actors have added extra references, invisible in the text but present in the articles' metadata, when they submitted the articles to scientific databases. The result? Citation counts for certain researchers or journals have skyrocketed, even though these references were not cited by the authors in their articles.'
https://phys.org/news/2024-07-scientific-fraud-uncovering.html
First was an excellent talk by Kyle Mahowald on using language models for #linguistics at UQAM | Université du Québec à Montréal. LLMs are considered to be very good at syntax and grammar, but is this due to memorization, heuristics, or building up a decent model of language? Through a systematic review controlling training data on smaller models, Mahowald convincingly demonstrates that it's the latter, exploring implications for linguistics. Highly recommend https://www.youtube.com/watch?v=z8SwDlv0jx4 (2/7) #AI
Confrontations in South China Sea surge, raising fears a miscalculation could lead to conflict
'The activation of the STING–MAPK–CREB signaling pathway induces the expression of many cytokine genes, including interleukin-2 (IL-2) and transforming growth factor-beta 2 (TGF-β2), to promote the Treg differentiation.'
Behold!
'The mayor wheeled the new NYC Bin down Gracie Mansion’s driveway and, with his characteristic swagger, demonstrated how the innovative new technology works: you open the lid and you put the rubbish in. It’s highly intuitive technology.'
Of course Russia.
#ClarenceThomas Accepted Yacht Trip to Russia, Chopper Flight to Putin’s Hometown https://www.thedailybeast.com/clarence-thomas-accepted-yacht-trip-to-russia-chopper-flight-to-putins-hometown-democrats
Covid deaths rise as booster vaccine take-up falls
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com