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Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters during collective cell migration of epithelial cells biorxiv.org/content/10.1101/20

'Big Tech's most aggressive privacy invaders have long flown Irish flags. Ireland is "headquarters" to Google, Meta, Tinder, Apple, Airbnb, Yahoo and many other tech companies. In exchange for locating a handful of jobs to Ireland, these companies are allowed to maintain the pretense that their global earnings are afloat in the Irish Sea, in a state of perfect, untaxable grace.'

pluralistic.net/2023/05/15/fin

Today marks the 41st anniversary of the day we all didn't die in an all-out nuclear holocaust. Happy Stanislav Petrov -day!

Here's a movie recommendation to match the occasion.

en.wikipedia.org/wiki/The_Man_

"Here, we present TIRTL-seq (Throughput-Intensive Rapid TCR Library sequencing), a novel approach that generates ready-to-sequence TCR libraries from live cells in less than 7 hours."

biorxiv.org/content/10.1101/20

OpenAI wants to open multiple 5 gigawatt data centers, which is "roughly the equivalent of five nuclear reactors". Each one would need more energy than an entire city or about 3 million homes.
arstechnica.com/tech-policy/20

"GPT-5 hasn’t dropped, Sora hasn’t shipped, the company had an operating loss of $5b last year. Company value: $150 billion dollars. Absolutely insane. Investors shouldn’t be pouring more money at higher valuations, they should be asking what is going on."

garymarcus.substack.com/p/open

'We wouldn’t allow a new drug to be sold without thorough testing for safety and efficacy, so why should AI be any different? Creating a “Food and Drug Administration for AI” may be a blunt metaphor, as the AI Now Institute has written, but it is time for governments to mandate AI safety testing.'
ft.com/content/8b190ef1-32d8-4

Anterior hypothalamic nucleus drives distinct defensive responses through cell-type-specific activity biorxiv.org/content/10.1101/20

@mouszi @pluralistic but it will need a scandal otherwise the 'security services + big tech' will block it.

Or it takes a few people at regulatory bodies with REAL integrity.

Cory Doctorow wrote a great essay about how the Irish have been shamefully protecting big tech. As an Irishman myself that was hard to read, but it was a wake up call:
pluralistic.net/2023/05/15/fin

'A bancada cita ainda dados da 'World Inequality Database', que refere que, em Portugal, "enquanto que em 1980 os 10% mais ricos detinham 12 vezes mais património do que os 50% mais pobres, neste momento, detêm mais de 17 vezes o património dos mais pobres, mesmo estes representando cinco vezes mais pessoas".

dn.pt/7637044009/livre-quer-qu

China’s scientists often cite work from their own nation. Is that skewing global research rankings?

Nation’s large size, but also questionable citation practices, could be inflating citation numbers, analysts say #press

science.org/content/article/ch

'First, the hosts Adam Cole and Joss Fong provide a brief history of Neanderthal discovery, as well as a rundown of how contemporary scientists view the Neanderthals’ place in evolutionary history today. Then, speaking with a series of experts, Cole takes a detailed dive into how, exactly, scientists arrived at the growing consensus that human-Neanderthal interbreeding means that there’s a little bit of Neanderthal in everyone’s family tree.'

aeon.co/videos/why-it-took-a-c

Want to quickly see which peripheral immune cells express your favorite gene across age? Check out the Immune Health Atlas Gene Expression Reference from the Allen Institute for Immunology!

apps.allenimmunology.org/aifi/

For more information about our cell type definitions, along with downloads, methods, and code, see the main page for the Human Immune Health Atlas:

apps.allenimmunology.org/aifi/

#OpenScienceWeek #Immunology

The Data-Driven Discovery: AI and Modeling in Biology Workshop is happening now at the Allen Institute.

I saw some great talks yesterday, and topics include protein design, neuroscience, physics, and immunology.

More info below, with links to recordings and the live stream, can be found here:

alleninstitute.org/events/data

#openscience #machinelearning #modeling

'Ms. Jones is an exemplary librarian at the Louisiana middle school she attended as a child. In 2022, as president of the Louisiana Association of School Librarians, she was well aware of the book-banning epidemic sweeping the country. When “book content” appears on the agenda of a library board meeting these days, the discussion generally concerns titles featuring L.G.B.T.Q. characters or subjects involving racism.'
nytimes.com/2024/09/23/opinion

'Para surpresa de muitos, a Faculdade de Ciências da Universidade de Lisboa (FCUL) planeia fechar o Departamento de História e Filosofia das Ciências – o único do nosso país. Se a decisão for para a frente, será lamentável não só para a FCUL mas para o país inteiro.'

expresso.pt/opiniao/2024-09-24

'Segundo a Oxfam, em 2019, 2.153 bilionários detinham mais riqueza do que 60% da população mundial. E desde então, as fortunas dos mais ricos continuam a bater recordes. De acordo com a Forbes, todos os bilionários com menos de 30 anos herdaram a sua fortuna, o que para o Livre “indica que um número crescente da riqueza advém do acumular de patrimónios passados, o que esbarra numa qualquer concepção meritocrática para a acumulação de capital”.

expresso.pt/politica/partidos/

Most of the energy debate is focused on the tip of the iceberg - electricity.

But almost 80% of our energy use is for heat and transport relying heavily on fossil fuels.

Decarbonisation requires an all-sector approach.

“The NYT cares more about its place in the power structure than in actually affecting that power structure. It cedes prominent column space to bad faith politicians who would like to eradicate whole demographics of the U.S. population. It dabbles in trans panic as a sort of weird hobby. And it scoffs at criticism from the progressive wing of the Democratic Party while going out of its way to heed criticism from a Republican Party.” sfgate.com/sf-culture/article/

'Euripides is the best represented of the Greek tragedians, which would have annoyed his contemporaries. He was lampooned in his day for his novel sonic effects, his corruption of Athenian values and his penchant for female protagonists and characters dressed in rags – an innovator, according to his critics, but not necessarily in a good way. In the end, he got the last laugh.'
lrb.co.uk/the-paper/v46/n18/ro

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