Thiago Carvalho @cyrilpedia@qoto.org

#pancreaticcancer is a deadly disease. New #trial data shows early benefits for addition of a personalized #mRNA #vaccine to #adjuvantchemotherapy after resection of the tumor. This feature in Deutsche Welle discusses the implications with Nina Bhardwaj and Drew Weissman #Immunotherapy #oncology https://t.co/j81AOXjcJS

@cyrilpedia Fully agreed! It is not understandable, why still no standard format for all first submissions exist...a simple json or XML type basic layout would be so easy and each journal could build a simple conversion tool to even produce PDFs automatically...

'A global comparison of the long-read data from young and aged mice showed an age-associated increase in the expression of noncoding transcripts, including IgV pseudogenes, lncRNAs and transcripts with retained introns (Supplementary Fig. 7). This is consistent with observations that an increased frequency of intron retention has been identified as a signature of ageing in fruitfly, mouse and human'

https://www.nature.com/articles/s42003-023-04936-6

AstraZeneca invests in Tregs

"One of the most promising UK biotech start-ups, Quell Therapeutics, has signed a research collaboration and licensing deal with AstraZeneca to develop treatments for two autoimmune diseases."

https://www.ft.com/content/92b0e9d5-22c1-4ddd-b135-52de8e200a48

It's official - we have a business! More news soon.

Celebrating with David del Álamo in Madrid.

This is just a ludicrous policy. Think of it this way: what would happen if Australia, Japan, South Africa or India asked for the lab notebooks of American researchers every three months? This is ill-considered policy, which will dissuade global health research. This is on NIH and HHS. They put this in place. They need to fix it.

https://www.nature.com/articles/d41586-023-01930-0

@halama_immuno @physorg_bot @gpollara Absolutely - but there are some very interesting details here, like this one "For instance, we find that bats have either lost CARD8 or have a CARD8 protein that is antagonized, rather than activated, by coronavirus 3CLpro cleavage."

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002144

June 9, 1891, French painter Paul Gauguin arrives in Papeete, Tahiti - a landscape of Tahiti with #volcano 🌋🖌️

"As of January 2023, the estimated prevalence of long Covid among people in the United States who had had acute infection was 11%. According to guidance released in August 2021 by the Department of Health and Human Services and the Department of Justice, long Covid can be considered a protected disability under the Americans with Disabilities Act (ADA) and under other disability-antidiscrimination mandates (such as Section 504 of the Rehabilitation Act and Section 1557 of the Affordable Care Act)."

#covid #longcovid #covid19

https://www.nejm.org/doi/full/10.1056/NEJMp2302676?query=featured_home

My Clinical Pipeline column for Nature Medicine this week examines the state of Sarepta's new gene therapy for Duchenne muscular dystrophy application at the FDA. Whatever its final efficacy turns out to be, the general strategy behind the therapy, an engineered micro-dystrophin is very clever.

It was inspired by the case of a 61 year old patient who had a deletion of almost half of his dystrophin gene and was still alive and walking. Here's that ref, from 1990:
https://www.nature.com/articles/343180a0

And here's my column:

https://www.nature.com/articles/d41591-023-00052-4

@physorg_bot This trip-wire has been around for awhile already... @gpollara @cyrilpedia

Referenced link: https://medicalxpress.com/news/2023-06-immune-wire-covid-.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-immune-wire-covid-.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1666867708095234049#m

RT by @physorg_com: Researchers find an #immunesystem 'trip wire' that detects #COVID-19 @ucsandiego @PLOSBiology https://journals.plos.org/plosbiology/article https://medicalxpress.com/news/2023-06-immune-wire-covid-.html

'These biofilms encase immune cells and establish a high local concentration of a secreted hemolysin to kill the immune cells before the biofilms disperse in a c-di-GMP-dependent manner.'

https://www.cell.com/cell/fulltext/S0092-8674(23)00527-5