Thiago Carvalho @cyrilpedia@qoto.org

Chloroplast protein import is controlled not just by the #ubiquitin-#proteasome system, but also by selective #NBR1-mediated selective #autophagy of translocon components in #Arabidopsis upon UV light or heat stress
https://www.embopress.org/doi/10.15252/embj.2022112534

A detailed study of the orphan receptor Nurr1, a regulator implicated in neurodegenerative diseases, reveals a new way for ligands to control their transcriptional activity. https://elifesciences.org/articles/89112?utm_source=twitter&utm_medium=social&utm_campaign=organic_insights

How does p97/VCP #ATPase achieve selective disassembly of regulatory protein complexes? #CryoEM showing #p97 holding on to one #PP1 partner, while threading another, suggest a hold-and-extract mechanism
Hemmo Meier, Helen Saibil and coworkers
https://www.embopress.org/doi/10.15252/embj.2022113110

On the passing of Daniel Ellsberg, I remember a quote from, I think, Timothy Garton Ash: if you keep something secret, in whatever context, you should be able to justify doing so when the secret is revealed. As a consequence, I think it is vital that secrets, even highly classified ones, are sometimes leaked. (I also happen to think Ellsberg was absolutely right to leak the Pentagon Papers.)

Strategic Masking to Protect Patients from All Respiratory Viral Infections
https://www.nejm.org/doi/full/10.1056/NEJMp2306223?query=TOC&cid=NEJM%20eToc,%20June%2015,%202023%20DM2236702_NEJM_Non_Subscriber&bid=1616356092

If your editorial website asks me to create a new login to suggest alternate reviewers when I decline to review myself, good luck finding alternate reviewers #Elsevier

An interesting story for the weekend: temperature dependent RNA editing in the octopus nervous system.

"In this study, we explore the effects of temperature on recoding across the neural transcriptome of Octopus bimaculoides, taking advantage of the extensive number of RNA editing sites in this species and its varied thermal environment"

https://www.cell.com/cell/fulltext/S0092-8674(23)00523-8

'To “pretend to understand a Book, by scouting thro’ the Index,” jibed Jonathan Swift in 1704, was the same “as if a Traveller should go about to describe a Palace, when he had seen nothing but the Privy.”

https://www.nybooks.com/articles/2023/06/22/life-is-short-indexes-are-necessary-dennis-duncan/

"Embrulhar Berlusconi neste manto de homem interessante e sedutor é inaceitável e é isso que vários políticos, comentadores e órgãos de comunicação social estão a fazer"

https://www.publico.pt/2023/06/14/opiniao/opiniao/romantizar-berlusconi-nao-informar-2053201

Reminder...Starting at 1 p.m. Eastern today: National Science Foundation @NSF listening session on its public access plan. #openscience https://new.nsf.gov/events/listen-learn-implementing-public-access-20/2023-06-02

"As entomologists ourselves, we are hugely grateful for the data collected by volunteers: We couldn’t do our work without them. But there’s a problem: There’s a huge imbalance in the data being collected."
—Entomologist Mary Gardiner and ecologist Helen Roy

Read more:
🐛 "Get out in your yard and count bugs," Knowable Magazine
https://arevie.ws/BugCountingOpEd

🐛 "The Role of Community Science in Entomology," Annual Review of Entomology
https://arevie.ws/BugCountingReview

#CitizenScience #entomology

'I can’t help but recall the story of Monowitz, the for-profit concentration camp the massive German chemicals conglomerate IG Farben built in 1942 four and a half miles from Auschwitz, after its plans to staff a rubber plant with slaves marched in from the camps each morning proved too costly and inefficient to deliver a speedy return on investment. So Farben bought 25,000 slave laborers, many of them children who were cheaper, to build a new camp next to the rubber plant, with even tighter living quarters and more inhumane treatment than the rest of Auschwitz.

At Monowitz, the beatings were so cruel the SS complained to Berlin, the hospitals so crowded that the SS repeatedly asked to build more; Farben refused on account of cost.'

https://prospect.org/culture/books/2023-06-02-days-of-plunder-morgenson-rosner-ballou-review/?ref=thebrowser.com

Gillian DeWane, Kris DeMali
and colleagues find that vinculin Y822 modulates ligand binding, and mutations at this residue affect focal adhesion morphology and contribute to tumorigenicity in cancer cells.
https://journals.biologists.com/jcs/article/136/12/jcs260104/316742/Vinculin-Y822-is-an-important-determinant-of

This article is available under our Read & Publish Open Access initiative.
Researchers can find out about the wide range of benefits, read what researchers are saying and view a list of participating institutions at https://www.biologists.com/library-hub/read-publish/researchers/
#OpenAccess #ReadandPublish