Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'You might think you should run to one of England’s small villages, away from the densely packed medieval city. Don’t. While fleeing the city would be a wise choice when faced with most pathogens, human density doesn’t dictate the bubonic plague’s spread. Instead, it’s the ratio of fleas to humans that matters most. The result is that most rat-infested farming villages had higher mortality rates than England’s cities.'
(via The Browser)
Thiago Carvalho
boosted
Videos of the #SIB course “Gene expression made useful easily: tools and database of Bgee” (Frederic Bastian & @marcrr):
Introduction of trainers https://www.youtube.com/watch?v=vjrTq0fGCTk
Overview of Bgee https://www.youtube.com/watch?v=x8Fypkwlmuw
Data integration in Bgee https://www.youtube.com/watch?v=hTx4fk77DZ4
Bgee data access https://www.youtube.com/watch?v=5cbXWL9quCA
Bgee tools https://www.youtube.com/watch?v=iUSjT9wDbmU
#biocuration #bioinformatics #RNAseq #SingleCell #GeneExpression #training
Thiago Carvalho
boosted
June 26, 1824, birthday of physicist William Thomson, better known as Lord Kelvin. His used thermodynamics to calculate #Earth's age* even if #geologists complained that "physics cannot be applied to #geology"* (*not exactly true) ⏰
https://americanscientist.org/article/kelvin-perry-and-the-age-of-the-earth
If a slipper falls on a rooftop visible from an exhibition, is it art? #discussamongstyourselves
Thiago Carvalho
boosted
@Odedrechavi @marcrr Every organism is named according to the narrowest well-known taxonomic group it shares with humans.
A chimp is a primate, a mouse is a mammal, a zebrafish is a vertebrate, a lancelet is a chordate, a fly or worm is a metazoan, and trypanosomes or plants are eukaryotes.
Thiago Carvalho
boosted
This really weird title for a C. elegans scRNA-seq atlas reminds me of @Odedrechavi who said that "metazoan" in a paper abstract means the work is about fly or nematode.
https://www.science.org/doi/10.1126/sciadv.adg0506
#SingleCell #nematode #Metazoa
“It’s stunning,” says the immunologist Barney Graham, the former deputy director of the Vaccine Research Center and a central figure in the development of mRNA vaccines, who has lately been writing about a “new era for vaccinology.” “You cannot imagine what you’re going to see over the next 30 years. The pace of advancement is in an exponential phase right now.”
https://www.nytimes.com/2023/06/23/magazine/golden-age-medicine-biomedical-innovation.html
Thiago Carvalho
boosted
Engineer with PhD in embedded systems
Elvesys - Elveflow
Do you have a #PhD and have skills in #EmbeddedSystems? Come join us in #Paris to build together the future of #microfluidics!
See the full job description on jobRxiv: https://jobrxiv.org/job/elvesys-elveflow-27778-engineer-with-phd-in-embedded-systems/?feed_id=48467
#ScienceJobs #hiring #research #EngineeringJobs @elveflow #PhDjobs ...
https://jobrxiv.org/job/elvesys-elveflow-27778-engineer-with-phd-in-embedded-systems/?feed_id=48467
Thiago Carvalho
boosted
Controlling for false discoveries subsequently to large scale one‐way ANOVA testing in proteomics: Practical considerations | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/pmic.202200406?af=R #proteomics
Thiago Carvalho
boosted
"Scientists warn that even a slight 0.8C (1.5F) increase in global #ocean temperatures represents “an enormous amount of #heat, large enough to transform marine #biodiversity, change ocean chemistry, raise #SeaLevels and fuel #ExtremeWeather”. "
Thiago Carvalho
boosted
Once someone makes the underlying assumptions explicit, you know what's coming next. Buckle up, tissue resident cell fate mapping, it's going to be a bumpy ride:
"Fate-mapping studies using conditional reporter genes and regulated expression of cre recombinase have led to the view that most resident tissue macrophage populations are established during embryonic development and maintained in the adult by self-renewal with minimal input from bone marrow progenitors or blood monocytes. The interpretation of fate-mapping studies depends upon multiple assumptions: (i) that expression of cre recombinase has no effect on monocyte-macrophage homeostasis, (ii) that tamoxifen is a neutral agonist, (iii) that life in an SPF animal facility reflects the normal life course of a mouse, and (iv) that the C57Bl/6J inbred mouse is a generalizable model and the biology of the MPS is unaffected by mouse genetic background or species."
Thiago Carvalho
boosted
Thiago Carvalho
boosted
'To address this critical knowledge gap, we conducted a comprehensive cross-species analysis of transcriptomic data from over 6000 blood samples from macaques and humans infected with one of 31 viruses, including #Lassa, #Ebola, #Marburg, #Zika, and #dengue.'
#Immunology #Virology #preprint
https://www.biorxiv.org/content/10.1101/2023.06.22.546003v1?med=mas
Thiago Carvalho
boosted
"King of censorship" is a good way of describing Musk
https://gizmodo.com/10-times-elon-musk-censored-twitter-users-1850570720
Thiago Carvalho
boosted
New video of Arthropod Antics finding "golden ants" in Costa Rica.
Once someone makes the underlying assumptions explicit, you know what's coming next. Buckle up, tissue resident cell fate mapping, it's going to be a bumpy ride:
"Fate-mapping studies using conditional reporter genes and regulated expression of cre recombinase have led to the view that most resident tissue macrophage populations are established during embryonic development and maintained in the adult by self-renewal with minimal input from bone marrow progenitors or blood monocytes. The interpretation of fate-mapping studies depends upon multiple assumptions: (i) that expression of cre recombinase has no effect on monocyte-macrophage homeostasis, (ii) that tamoxifen is a neutral agonist, (iii) that life in an SPF animal facility reflects the normal life course of a mouse, and (iv) that the C57Bl/6J inbred mouse is a generalizable model and the biology of the MPS is unaffected by mouse genetic background or species."
Thiago Carvalho
boosted
A great week at the soon to be extinct Gulbenkian Science Institute/IGC teaching MD PhD students of the EMERALD program.
Thiago Carvalho
boosted
Britain’s shorter children reveal a grim story about austerity, but its scars run far deeper | Michael Marmot https://www.theguardian.com/commentisfree/2023/jun/25/britains-shorter-children-reveal-a-grim-story-about-austerity-but-its-scars-run-far-deeper
Thiago Carvalho
boosted
Civilization dies when the only answer to "why can he do that?" is "because you can't stop him."
Thiago Carvalho
boosted
On this day in 1991: Michael Heidelberger died aged 103, key pioneer of immunochemistry #ThisDayInBiotech
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
