Thiago Carvalho @cyrilpedia@qoto.org

Aprender a filosofar no ensino secundário: orientações curriculares e didáticas para integração do pensamento crítico https://ria.ua.pt/handle/10773/41550 https://social.dfaria.eu/?hashtag=2024-04-17T22:58:46Z

"Compared to 2021, we now have almost seven times as many editors in Latin America and more than five times as many in Africa. Specifically, while Latin American and African editors combined made up less than 1% of our editorial board in our last report, currently 7% of eLife editors are based in Latin America and 3% are based in Africa (Figure 1). The number of eLife editors in Asia has also grown, at the moment constituting 14% of our editorial board compared to 11% in 2021."

https://elifesciences.org/inside-elife/e3b5c5c9/elife-latest-2024-update-on-the-diversity-of-our-editorial-community

'A Universidade de Buenos Aires, a maior e mais prestigiada instituição de ensino superior na Argentina, está em emergência orçamental e corre o risco de poder deixar de funcionar nos próximos meses. A direcção aponta o dedo ao Governo de Javier Milei, que se recusou a rever o orçamento disponível para a universidade.'

https://www.publico.pt/2024/04/16/mundo/noticia/funcionamento-maior-universidade-argentina-risco-causa-cortes-2087230

"We are going to put on the armor of God. And maybe strap on a Glock on the side of us just in case." -AZ Senate candidate Kari Lake

The blending of White Christian Nationalism and increasingly overt calls for violence is a dangerous combination.

This one goes out to anybody who has ever picked up a feather and wondered how they work (short answer: they're amazing) https://www.scientificamerican.com/article/why-feathers-are-one-of-evolutions-cleverest-inventions/

Home away from home for a few months this year: at the Center fro Cancer Immunotherapy & Immunobiology at the University of Kyoto, newly established by Prof. Tasuku Honjo.

https://www.ccii.med.kyoto-u.ac.jp/en/

The FDA has approved Merck's sotatercept for pulmonary arterial hypertension.

I wrote about this activin receptor IIA (TGF-β family member) & human immunoglobulin IgG1 Fc domain fusion protein at the end of 2022:
"Studies of familial disease have found that over 70% of cases have mutations in the BMPR2 gene, which encodes the TGF-β (transforming growth factor-β) family member BMPR-II (bone morphogenetic protein type II receptor), or in genes encoding molecules in the BMPR-II signaling pathway. Mutations in the BMPR-II pathway are also seen in idiopathic cases, and patients with BMPR2 mutations have an earlier age of onset and a more severe course of the disease."

https://www.nature.com/articles/d41591-022-00109-w

'Ex vivo staining of patient tumour tissue shows the formation of an acid wall below pH 5.3 at the stromal–tumour tissue interface with exclusion of CD8+ T cells (Fig. 4c). We theorize that polarized secretion of lactic acid creates exclusionary zones that exterminate CD8+ T cells upon cell–cell contact, which offers a survival advantage for cancer cells with strong acidotic properties'
https://www.nature.com/articles/s41551-024-01178-7#Sec10

'On our trip, I finished reading Galileo: Watcher of the Skies; the author, the British historian David Wootton, does an excellent job of conjuring up the intellectual world that produced Galileo. It was a crowded community of scholars who championed many different views about how the world worked. Some became Galileo's champions, others his rivals. Wootton makes it clear that Galileo was a part of that world, not floating above it.'
@Carl_Zimmer

https://buttondown.email/carlzimmer/archive/fridays-elk-april-13-2024/

'Seventy-five percent of the references in NCBI/PubMed to the search word “symbiosis” (first present in 1913) have been published since 2006, as have 99% of the references to “microbiota” (first appearing in 1956). This new knowledge base will change subdisciplines of biology to varying degrees. Some areas, such as biomechanics, are likely to be little affected, but others, including immunology and developmental biology, evolutionary biology, and neurobiology, are already experiencing a reshaping as symbiosis is incorporated into their research frameworks.'

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002571

'In Brazil, the Oswaldo Cruz Foundation, a vaccine manufacturer and the largest biomedical research institute in Latin America, recently partnered with a US-based nonprofit called Caring Cross to help develop local CAR-T manufacturing capabilities. Caring Cross has developed a point-of-care manufacturing process able to generate CAR-T therapies for an even lower cost—roughly $20,000 in materials and $10,000 in labor and facilities.'
#Immunology #Immunotherapy #CARTcells

https://www.technologyreview.com/2024/04/12/1091161/car-t-cancer-therapy-treatment-expense/

If you're a young person & unsure about whether the UK dropping out of Erasmus is important, here's an immediate lost opportunity - while the UK was not an eligible country, it could have opted into Erasmus + so you could have taken advantage of this programme of a months free rail travel in Europe... but unfortunately the Tories decided you really would wan that... sorry.

#Brexit #Erasmus #youngpeople

https://youth.europa.eu/discovereu_en

I am looking for candidates for 54-months (!) Lead resarch technician position, working on my #ERC project, developing haplotagging methods, managing data and helping with field work. More information here :
https://euraxess.ec.europa.eu/jobs/225940

Exciting opportunity to work in Paris, in the middle of the Jardin des Plantes, with a great (and humble) supervisor.

Please boost!

#Job #France #Evolution #EvolutionaryBiology #Genetics #Genomics

@jobsecoevo

"today's hearing is setting a dangerous precedent that if Congress doesn't like what you publish you'll be hauled in before a congressional committee to answer for it...Congress should not be meddling in the peer review process"

House Select Committee calls @holden of Science https://www.youtube.com/watch?v=XBmWQJ4vdWA&t=1s 1/3