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New story: Scientists have created a version of HIV that cheats its fellow HIV viruses. An upcoming clinical trial will test whether it can work as a new kind of antiviral drug. 1/3

"Imagine um país no qual autores, escritores e ilustradores são assediados por bandos organizados que os ameaçam nas redes e intimidam verbal e fisicamente de cada vez que estes apresentam os seus livros. Não precisa de imaginar muito longe: esse país é Portugal. Agora imagine o que acontece a seguir: nada."
expresso.pt/opiniao/2024-08-08

A Turing machine cannot physically exist, but its reasoning laid the intellectual foundation for the invention of the electronic computer. Here's how they work: quantamagazine.org/alan-turing

New in PN: Elon Musk tries to dismantle the foundations of US democracy

From blatant election interference to ending the NLRB to trying to force companies to advertise on X, Musk is doing all kinds of damage — and so far he's getting away with it. publicnotice.co/p/elon-musk-el

'Helsinki recorded no deaths for the first time since records began in 1960, down from an average of 20-30 a year in the 1990s. In Oslo, there were also no pedestrian or cyclist deaths in the city, which has a population of 680,000, and no children under 16 died in traffic crashes in the entire country.'
theguardian.com/world/2020/mar

 
…"at high speeds & tiny scales — those intuitions cease to serve us, making it impossible for us to do science without confronting our philosophical assumptions head-on. Suddenly we find ourselves in a place where #science and #philosophy can no longer be neatly distinguished. A place, according to the physicist Eric Cavalcanti, called #experimental #metaphysics”…

🔗 QuantaMagazine.org/metaphysica
🔗 experts.griffith.edu.au/8103-e

#Time #Timelessness #TimeTravelThinkers #EricCavalcanti #MetaPhysics

CEO: "Forgive me, Father, for I have sinned. My company emitted one million tonnes of CO₂ and contributed to climate change."

Priest: "Say three Hail Marys and pay $250 to plant 1000 trees."

CEO: "Thank you, Father."

'Daiichi is buying into the development of MK-6070, a trispecific T-cell engager that Merck acquired when it bought Harpoon for $650 million earlier this year. MK-6070, formerly known as HPN328, is designed to bind CD3 on T cells and DLL3 on tumor cells. The third domain binds albumin to extend the half-life.'

fiercebiotech.com/biotech/merc

'That puts the dinosaur story into unusual company. Every once in a great while, people going about their ordinary lives have looked up and seen something they never imagined. A ship with towering masts and billowing sails materialized on the horizon, for instance, in waters that had never known a vessel bigger than a canoe. Or a stranger turned up in a valley so remote that its inhabitants had thought themselves alone in the world.'

lithub.com/giants-bones-fossil

A magnitude 5.3 earthquake, measuring a lower 5 on Japan's seismic intensity scale, shook the Kanto region on Friday evening. There was no threat of a tsunami. japantimes.co.jp/news/2024/08/ #japan #earthquakes #disasters

'Some of the effects of this have been typical, like the landlords who have converted apartments to short-term rentals, which has raised rents and sent students farther from the university and into the smaller towns on the periphery. But one result has been very particular to Bologna: the consumption of mind-numbing, heart-stopping amounts of mortadella.'

nytimes.com/2024/08/09/opinion

Computational Immunologist - Scientist I

Vaccine and Infectious Disease Organization (VIDO)

The Vaccine and Infectious Disease Organization (VIDO) is looking for a Computational Immunologist - Scientist 1 to join us in Saskatoon, SK.

See the full job description on jobRxiv: jobrxiv.org/job/vaccine-and-in...
jobrxiv.org/job/vaccine-and-in

'In medicine, the traditional model for researching disabilities repeats itself again and again: nondisabled researchers conduct their studies ‘on’ disabled people as their subjects. While there may be nothing inherently wrong with this mode of scholarship, it carries limitations that should be acknowledged. The fact is: patients can have different priorities from clinicians.'
aeon.co/essays/we-need-the-fir

'People carried signs reading “Not in our city,” and “Will trade racists for refugees.”
“They all had one thing in mind; it was to not let this hate get a foothold,” said Ewan Roberts, who manages Asylum Link Merseyside, the charity that was on the target list.'
nytimes.com/2024/08/09/world/e

Therapeutic targeting of Syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers biorxiv.org/content/10.1101/20

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