Thiago Carvalho @cyrilpedia@qoto.org

'Maid’s rooms have been a fixture in Brazil’s homes for generations, a vestige of its long history of slavery and a tangible marker of inequality in a country where, after abolition, many affluent families relied on low paid, mostly Black domestic workers to clean, cook and care for children. Some worked around the clock for pennies; others toiled only in exchange for room and board.'
https://www.nytimes.com/2024/08/15/world/americas/brazil-maid-rooms-racist-past.html

'Urgent efforts to roll out vaccines to tackle the Mpox international public health emergency in central and east Africa risk being hobbled by a lack of orders and logistical challenges, a leading vaccine manufacturer has said.'
https://www.ft.com/content/47e34535-2fe5-4a87-a255-2a17c1e2e8fd

'In addition to illuminating previously overlooked factors relevant to intracellular macrophage pathogenesis and chronic infection, these studies highlight pronounced differences between the results of in vivo and in vitro investigatory strategies. Macrophage pathogenesis phenotypes quantitatively increased during both chronic human infection and serial passaging, and most genes implicated by in vivo and in vitro strategies were confirmed to impact macrophage pathogenesis in the same functional laboratory model. Yet, despite these phenotypic similarities, only a single candidate gene was identified in common by parallel in vivo and in vitro studies.'

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012394

'A larger number of S. aureus macrophage pathogenesis genes (n = 27) are newly implicated by this effort, comprising 61% of genes passing experimental validation. The putative or documented roles of many mirror the functions of known virulence factors (…) However, other newly validated genes offer insight into previously unappreciated mechanisms affecting intracellular macrophage pathogenesis. The most substantial constellation of functionally related genes include fmhA [99], femA [100], femB [100], and pbp2 [100], all of which have functions in peptidoglycan assembly.'

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012394

'Por esta altura, os principais indicadores usados para medir a sobrecarga turística estão, em Lisboa e no Algarve, ao nível ou acima daqueles que se verificam em cidades como Barcelona ou Amesterdão, onde já há restrições pesadas à actividade turística.'

https://www.publico.pt/2024/08/15/economia/noticia/sobrecarga-turistica-lisboa-algarve-nivel-barcelona-amesterdao-2100503?ref=hp&cx=manchete_2_destaques_0

'Swiss drugmaker Roche turned down a potential $14bn-a-year weight-loss pill now being developed by rival Eli Lilly that could have given it a leading position in the booming weight-loss market, according to company filings and people close to discussions.'

https://www.ft.com/content/78057a2c-60b8-410f-8731-b7c787991a57

'Now, a handful of health care companies are preparing to introduce a new model for cervical cancer screening and prevention that would circumvent the speculum: self-collection, in which a woman swabs her vagina in the doctor’s office, using only a narrow swab that looks similar to the one used during a Covid test. Once the sample is collected, a lab would test it for the strains of human papillomavirus, or HPV, most likely to cause cervical cancer.'
https://www.nytimes.com/2024/08/15/well/pap-smear-cervical-cancer-test-alternative.html

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