@BartoszMilewski - In his novel "Permutation City", Egan has some characters deal with this by having an 'exoself' that occasionally steps in and sets new psychological parameters to keep things interesting. Even this could get boring *eventually*, but it's an interesting idea. For example one character decides to make themselves fascinated by carpentry until they can reliably craft wonderful furniture. Then the exoself steps in and the character switches to entomology. There is still an odor of futility here.
@BartoszMilewski @johncarlosbaez The Culture has 400 years cutoff, which seems... arbitrarily little to the point of being "deathist".