Gaspar Jekely @jekely@qoto.org
- Platynereis connectome
- https://catmaid.jekelylab.ex.ac.uk
Professor at Centre for Organismal Studies (COS), University of Heidelberg, Germany
and
Living Systems Institute (LSI), University of Exeter, UK.
#neuroscience of marine larvae, #connectomics, #cilia, ciliary swimming, cell and nervous system #evolution, #GPCR, #neuropeptides, #Platynereis, #Trichoplax, #Nematostella, #Schistosoma, #coral #neuroscience #rstat #evolution
Joined Nov 2022
Gaspar Jekely
boosted
#introduction
I'm a theoretical neuroscientist in Paris.
These days I'm working on biophysics of action potentials (particularly the initial segment) and on integrative modeling of Paramecium, the “swimming neuron” (this is a unicellular protist that changes swimming direction with action potentials).
I also spend some time thinking about the relations between theoretical biology and theoretical neuroscience, ideas about life and ideas about brains.
Gaspar Jekely
boosted
3,013 neurons, half a million synapses: the complete #connectome of the whole #Drosophila larval brain!
Winding, Pedigo et al. 2022. "The connectome of an insect brain" https://www.biorxiv.org/content/10.1101/2022.11.28.516756v1
We’ve mapped and analysed its circuit architecture, from sensory neurons to brain output neurons, as reconstructed from volume electron microscopy, and here is what we found. 1/
Gaspar Jekely
boosted
Not nearly enough #protists and #cilia in this universe yet... let's rectify this with an inaugural edition of #CiliaSaturday 😍
Look at all its beautiful 'feet'... !
Gaspar Jekely
boosted
New postdoc position to join my group at the Sars Centre, in #SunnyBergen https://www.jobbnorge.no/en/available-jobs/job/236193/postdoctoral-research-fellow-position-developmental-systems-in-a-simple-marine-chordate
Our review with Stefan Gründer and Audrey Ortega Ramírez is out:
"Neuropeptides and DEG/ENaC ion channels: a relationship from mammals to cnidarians"
where we conclude based on structural comparisons and the #phylogeny of #neuropeptide systems that the interaction of DEG/ENaC channels with neuropeptides has diverse structural bases and many origins.
Gaspar Jekely
boosted
@jekely too late. I deleted my Twitter account. Why keep feeding the troll? Engagement earns them ad revenue.
Gaspar Jekely
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Hi, we're now on Fediscience! #Introduction
We're an #OpenAccess not-for-profit journal that publishes and reviews #research in the life and biomedical sciences.
We want to improve the way research is practised and shared in part by working with early-career researchers #ECR and supporting #OpenSource technology.
We also just announced our new publishing model that we hope will tackle an overreliance on journal titles and publishing decisions as quality measures for science and scientists.
Gaspar Jekely
boosted
Dear fellow Mastodoners, To help the #TwitterMigration I only post teazers on twitter with a link to the mastodon content and a short message:
"Join us on the other side. Open, distributed, community driven, no ads, no AI feeding you, no random retweets, full control."
you could do the same
Finally, here is the Editor's evaluation from @elife
This paper reports on the development of an impressive microfluidic platform for the study of motility, and motility transitions, exhibited by single algal cells in circular confinement. Building on previous work that showed a three-state motility repertoire for certain green algae, the present work uses extremely long time series and a variety of physical perturbations to show how those dynamics can be altered by environmental conditions. The work will be of interest to a wide range of scientists studying motility and non-equilibrium dynamics.
https://doi.org/10.7554/eLife.76519.sa0
The authors also developed and tested a novel droplet-fusion assay to expose single cells in a controlled manner to chemicals. This could be a very elegant way to e.g., dissect #signalling mechanisms in the cells by #pharmacology.
The motility is light-switchable, which was known, but the long-term imaging of single cells in light and dark revealed a cellular #memory: the light-altered behavioural state persisted after light off.
The locomotion of single-cells is characterised by a trio of motility macrostates (run, stop, tumble) with distinct transition probabilities that could be quantified by long-term imaging.
#Chlamydomonas (2 #cilia) and #Pyramimonas (8 cilia) #algae were encapsulated into droplets by #microfluidics and imaged at high speed to characterise gait switching dynamics and the effect of light.
Great paper: a droplet #microfluidics assay to encapsulate single micron-sized algae to study long-term #behaviour.
https://elifesciences.org/articles/76519#fig4
by Bentley et al. gielenlab.com and @micromotility
A thread.
Gaspar Jekely
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Hello, #GEOMAR is #newhere on Mastodon.
We are the Helmholtz Centre for #OceanResearch based in #Kiel, Germany.
We study the global #ocean from the #seafloor to the #atmosphere, covering a spectrum of physical, chemical, biological and geological processes in the ocean.
Follow us for the latest news from #oceanscience and #climateresearch and feel free to check out our website:
www.geomar.de/en
Member of the #Helmholtz community @helmholtz
Gaspar Jekely
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Hi #ScienceMastodon, time for an #introduction!
I'm an #EvoDevo biologist interested in how tissue #mechanics influences the #evolution of #morphogenesis. I study a deep and mysterious epithelial invagination that forms at the head-trunk boundary of #flies during #gastrulation, known as the #CephalicFurrow (see video below!). Currently, based in Germany as a postdoc in the Tomancak Lab at MPI-CBG. Looking forward to meeting you!
Gaspar Jekely
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RT @GRC_CMM
Hey #cilia & #centriole tweeps- we are just under two weeks from our deadline ⏳December 5th⏳ for abstracts for talk slots at 2023 GRC Cilia, Mucus and Mucociliary meeting in Barga, Italy! #RareDisease #Therapeutics #Biophysics #Biofilms #Mucus #CF #PCD https://www.grc.org/cilia-mucus-and-mucociliary-interactions-conference/2023/
Gaspar Jekely
boosted
4 yr PhD in Manchester, UK: The evolution of nerves: understanding the roots of neurodegeneration
TRAINING in evol. biol., biochem., expansion or electron microsc., cell culture, #Drosophila genetics, #scicomm
SUPERVISION: Prokop/Allan/Ronshaugen
The paper is by Justine M Pinskey et al. Daniela Nicastro's lab - are you on Mastodon?
- Platynereis connectome
- https://catmaid.jekelylab.ex.ac.uk
Professor at Centre for Organismal Studies (COS), University of Heidelberg, Germany
and
Living Systems Institute (LSI), University of Exeter, UK.
#neuroscience of marine larvae, #connectomics, #cilia, ciliary swimming, cell and nervous system #evolution, #GPCR, #neuropeptides, #Platynereis, #Trichoplax, #Nematostella, #Schistosoma, #coral #neuroscience #rstat #evolution
Joined Nov 2022
