jonmoulton @jonmoulton@qoto.org

Use of vivo-morpholinos for gene knockdown in the postnatal shark retina. https://www.sciencedirect.com/science/article/pii/S0014483522004146 Vivo-#Morpholino

Loss of Apical Sodium Bile Acid Transporter Disrupts Bile Acid Circulation and Reduces Biliary Damage in Cholangitis. https://journals.physiology.org/doi/abs/10.1152/ajpgi.00112.2022 Vivo-#Morpholino

Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1054/6833243 #Morpholino

Hnf1b renal expression directed by a distal enhancer responsive to Pax8. https://www.nature.com/articles/s41598-022-21171-x #Morpholino

Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells. https://www.embopress.org/doi/abs/10.15252/embr.202254984 #Morpholino

The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1031962/full #Morpholino

Developing Therapeutic Splice-Correcting Antisense Oligomers for Adult-Onset Pompe Disease with c.-32-13T>G Mutation. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_14 #Morpholino

Peptide-Conjugated PMOs for the Treatment of Myotonic Dystrophy.
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_13 #Morpholino

Morpholino-Mediated Exons 28–29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_11 #Morpholino

Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_7
#Morpholino

Restoring Dystrophin Expression by Skipping Exons 6 and 8 in Neonatal Dystrophic Dogs. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_6 #Morpholino

Viltolarsen: From Preclinical Studies to FDA Approval. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_2 #Morpholino

DNAJB6 Isoform Specific Knockdown: Therapeutic Potential for LGMDD1. https://www.biorxiv.org/content/10.1101/2022.11.17.516920v1 #Morpholino

Functional identification of the zebrafish Interleukin-1 receptor in an embryonic model of Il-1β-induced systemic inflammation. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1039161/full #Morpholino

An ancestral Wnt–Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes. https://www.nature.com/articles/s41559-022-01905-w #Morpholino

Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276255 #Morpholino

NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae. https://www.micropublication.org/journals/biology/micropub-biology-000682 #Morpholino

Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation. https://www.mdpi.com/1422-0067/23/22/14182 #Morpholino

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. https://www.sciencedirect.com/science/article/abs/pii/S1934590922004271 #Morpholino

X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems. https://jmg.bmj.com/content/early/2022/11/15/jmg-2022-108738 #Morpholino