jonmoulton @jonmoulton@qoto.org

(Brief article): Dyne Therapeutics: Positive Initial Clinical Data from DMD DELIVER Trial. https://defeatduchenne.ca/dyne-therapeutics-positive-initial-clinical-data-from-dmd-deliver-trial/ #Morpholino

The RhoGEF Trio is transported by microtubules and affects microtubule stability in migrating neural crest cells. https://www.sciencedirect.com/science/article/pii/S266729012300075X #Morpholino

Histone lactylation couples cellular metabolism with developmental gene regulatory networks. https://www.nature.com/articles/s41467-023-44121-1 #Morpholino

(Article): Clinical Potential of AOC 1044 in Treating Duchenne Muscular Dystrophy Amenable to Exon 44 Skipping. https://www.neurologylive.com/view/clinical-potential-aoc-1044-treating-duchenne-muscular-dystrophy-amenable-exon-44-skipping #Morpholino

Development of FKBP5 ASOs to mitigate tau pathology. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.082780 Vivo-#Morpholino

AMONDYS 45 (Casimersen), a Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations for Treatment in Duchenne Muscular Dystrophy. https://www.cureus.com/articles/215610-amondys-45-casimersen-a-novel-antisense-phosphorodiamidate-morpholino-oligomer-clinical-considerations-for-treatment-in-duchenne-muscular-dystrophy#!/ #Morpholino

Loss of coactosin-like F-actin binding protein 1 (Cotl1) decreases platelet-mediated osteoclastogenesis and causes osteopetrosis phenotypes in mouse. https://www.medrxiv.org/content/10.1101/2023.12.20.23300337v1 #Morpholino

Cost-effective strategies to knock down genes of interest in the retinas of adult Zebrafish. https://www.frontiersin.org/articles/10.3389/fncel.2023.1321337/abstract Vivo-#Morpholino

TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning. https://www.biorxiv.org/content/10.1101/2023.03.29.534583v3 #Morpholino

Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina. https://www.nature.com/articles/s41467-023-44142-w #Morpholino

β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition. https://www.cell.com/iscience/fulltext/S2589-0042(23)02546-4 #Morpholino

BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles. https://www.pnas.org/doi/10.1073/pnas.2316542121 #Morpholino

SH2 domain protein E and ABL signaling regulate blood vessel size. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010851 #Morpholino

The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development. https://academic.oup.com/jmcb/advance-article/doi/10.1093/jmcb/mjad083/7511116 #Morpholino

ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation. https://www.embopress.org/doi/full/10.1038/s44319-023-00046-w #Morpholino

CLN3 deficiency leads to neurological and metabolic perturbations during early development. https://www.life-science-alliance.org/content/7/3/e202302057 #Morpholino

Identification of End-Binding 1 Protein as Novel α-4 Giardin-Binding Partners in Giardia lamblia Trophozoites. https://link.springer.com/article/10.1007/s11686-023-00774-y #Morpholino

Iprodione induces hepatotoxicity in zebrafish by mediating ROS generation and upregulating p53 signalling pathway. https://www.sciencedirect.com/science/article/pii/S014765132301415X #Morpholino

Damage-induced basal epithelial cell migration modulates the spatial organization of redox signaling and sensory neuron regeneration. https://www.biorxiv.org/content/10.1101/2023.03.14.532628v2 #Morpholino

Antagonistic regulation of homeologous uncx.L and uncx.S genes orchestrates myotome and sclerotome differentiation in the evolutionarily divergent vertebral column of Xenopus laevis. https://onlinelibrary.wiley.com/doi/10.1002/jez.b.23235 #Morpholino