jonmoulton @jonmoulton@qoto.org

Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: study protocol for a phase I/II clinical trial. https://www.medrxiv.org/content/10.1101/2023.02.06.23285500v1 #Morpholino

Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration. https://www.mdpi.com/1422-0067/24/4/3253 Vivo-#Morpholino

Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. https://www.pnas.org/doi/10.1073/pnas.2212212120 #Morpholino

Gaucher disease protects against tuberculosis. https://www.pnas.org/doi/10.1073/pnas.2217673120 #Morpholino

The Moulton lab (My wife Hong at OSU, the PPMO lady) has it's stable domain name now. moultonlab.org
#Morpholino-peptide conjugates

Ubiquitylation of BBSome is required for ciliary assembly and signaling. https://www.embopress.org/doi/full/10.15252/embr.202255571 #Morpholino

Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs. https://journals.lww.com/jasn/Abstract/2023/02000/Genetic_Variants_in_ARHGEF6_Cause_Congenital.14.aspx #Morpholino

Confined environments induce polarized paraspeckle condensates. https://www.nature.com/articles/s42003-023-04528-4 #Morpholino

Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins. Review.
https://link.springer.com/article/10.1007/s12272-023-01429-2
#Morpholino

Tmem88 confines ectodermal Wnt2bb signaling in pharyngeal arch artery progenitors for balancing cell cycle progression and cell fate decision. https://www.nature.com/articles/s44161-023-00215-z #Morpholino

DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration . https://insight.jci.org/articles/view/160516 #Morpholino

(Article): Unlocking New Possibilities in Research, Therapeutics, and Beyond with #Morpholino Antisense Oligos. https://www.pharmasalmanac.com/articles/unlocking-new-possibilities-in-research-therapeutics-and-beyond-with-morpholino-antisense-oligos

RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00058-X #Morpholino

The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs. https://www.nature.com/articles/s41467-023-36114-x #Morpholino

The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-03895-0 #Morpholino

Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries. https://www.jhep-reports.eu/article/S2589-5559(22)00224-5/fulltext #Morpholino

My wife's lab's website: not a #Morpholino paper, but certainly Morpholino related! She makes delivery-enabled Morpholino conjugates (e.g. PPMOs). https://athos213.github.io/MoultonResearchGroup/

Crb3 stabilizes activated Ezrin-Radixin-Moesin to organize the apical domain of multiciliated cells. https://www.biorxiv.org/content/10.1101/2023.01.24.525309v1 #Morpholino

Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. https://www.sciencedirect.com/science/article/pii/S1534580722008954 #Morpholino

Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling. https://www.nature.com/articles/s41467-023-35991-6 #Morpholino