jonmoulton @jonmoulton@qoto.org

Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11. https://www.nature.com/articles/s41467-022-34909-y #Morpholino

Microenvironmental Snail1 is a driver of immunosuppression in melanoma. https://www.biorxiv.org/content/10.1101/2022.11.23.517623v1 Vivo-#Morpholino

N-Fluoroalkylated Morpholinos – a New Class of Nucleoside Analogues. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202203248 #Morpholino

Use of vivo-morpholinos for gene knockdown in the postnatal shark retina. https://www.sciencedirect.com/science/article/pii/S0014483522004146 Vivo-#Morpholino

Loss of Apical Sodium Bile Acid Transporter Disrupts Bile Acid Circulation and Reduces Biliary Damage in Cholangitis. https://journals.physiology.org/doi/abs/10.1152/ajpgi.00112.2022 Vivo-#Morpholino

Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1054/6833243 #Morpholino

Hnf1b renal expression directed by a distal enhancer responsive to Pax8. https://www.nature.com/articles/s41598-022-21171-x #Morpholino

Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells. https://www.embopress.org/doi/abs/10.15252/embr.202254984 #Morpholino

The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1031962/full #Morpholino

Developing Therapeutic Splice-Correcting Antisense Oligomers for Adult-Onset Pompe Disease with c.-32-13T>G Mutation. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_14 #Morpholino

Peptide-Conjugated PMOs for the Treatment of Myotonic Dystrophy.
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_13 #Morpholino

Morpholino-Mediated Exons 28–29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_11 #Morpholino

Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_7
#Morpholino

Restoring Dystrophin Expression by Skipping Exons 6 and 8 in Neonatal Dystrophic Dogs. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_6 #Morpholino

Viltolarsen: From Preclinical Studies to FDA Approval. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_2 #Morpholino

DNAJB6 Isoform Specific Knockdown: Therapeutic Potential for LGMDD1. https://www.biorxiv.org/content/10.1101/2022.11.17.516920v1 #Morpholino