Crb3 stabilizes activated Ezrin-Radixin-Moesin to organize the apical domain of multiciliated cells. https://www.biorxiv.org/content/10.1101/2023.01.24.525309v1 #Morpholino
Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. https://www.sciencedirect.com/science/article/pii/S1534580722008954 #Morpholino
Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling. https://www.nature.com/articles/s41467-023-35991-6 #Morpholino
Integrative genetic analysis illuminates ALS heritability and identifies risk genes. https://www.nature.com/articles/s41467-022-35724-1 #Morpholino
Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. https://www.pnas.org/doi/10.1073/pnas.2208941120 #Morpholino
Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_11 #Morpholino
Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer’s Disease Pathogenesis. https://www.mdpi.com/2073-4409/12/3/376/htm #Morpholino
SMIM36, a novel and conserved microprotein, is involved in retinal lamination in zebrafish. https://www.biorxiv.org/content/10.1101/2023.01.14.524032v1 #Morpholino
Multiple pkd and piezo gene family members are required for atrioventricular valve formation. https://www.nature.com/articles/s41467-023-35843-3 #Morpholino
Identification of the Time Period during Which BMP Signaling Regulates Proliferation of Neural Progenitor Cells in Zebrafish. https://www.mdpi.com/1422-0067/24/2/1733 #Morpholino
Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis. https://link.springer.com/article/10.1007/s10456-023-09865-w #Morpholino
Inducible in vivo genome editing in the sea star Patiria miniata. https://www.biorxiv.org/content/10.1101/2023.01.09.523328v1 #Morpholino
Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease. https://journals.lww.com/jasn/Abstract/2022/08000/Channel_Function_of_Polycystin_2_in_the.13.aspx #Morpholino
Somitic mesoderm morphogenesis is necessary for neural tube closure during Xenopus development. https://www.frontiersin.org/articles/10.3389/fcell.2022.1091629/full #Morpholino
Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs. https://www.pnas.org/doi/abs/10.1073/pnas.2215071120 #Morpholino
Hydrozoan sperm-specific SPKK motif-containing histone H2B variants stabilise chromatin with limited compaction. https://journals.biologists.com/dev/article/150/1/dev201058/286546/Hydrozoan-sperm-specific-SPKK-motif-containing #Morpholino
C5-pyrimidine-functionalized morpholino oligonucleotides exhibit differential binding affinity, target specificity and lipophilicity. https://pubs.rsc.org/en/content/articlelanding/2023/OB/D2OB01759H #Morpholino
Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs. https://www.nature.com/articles/s41598-022-26614-z #Morpholino
maea affects head formation through ß-catenin degradation during early Xenopus laevis development. https://onlinelibrary.wiley.com/doi/10.1111/dgd.12828 #Morpholino
Distinct biogenesis pathways may have led to functional divergence of the human and Drosophila Arglu1 sisRNA. https://www.embopress.org/doi/abs/10.15252/embr.202154350 #Morpholino
It's been all Morpholinos all the time for about 23 years. I'm a scientist with Gene Tools LLC.