jonmoulton @jonmoulton@qoto.org

Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach. https://www.nature.com/articles/s41598-023-38698-2 #Morpholino

Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans. https://www.science.org/doi/10.1126/scitranslmed.adf2059 Vivo-#Morpholino

Aicardi Syndrome Is a Genetically Heterogeneous Disorder. https://www.mdpi.com/2073-4425/14/8/1565 #Morpholino

Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development. https://www.frontiersin.org/articles/10.3389/fcell.2023.1168643/full #Morpholino

Microenvironmental Snail1-induced immunosuppression promotes melanoma growth. https://www.nature.com/articles/s41388-023-02793-5 #Morpholino

mRNA location and translation rate determine protein targeting to dual destinations. https://www.sciencedirect.com/science/article/pii/S1097276523005142 #Morpholino

Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping. https://www.mdpi.com/1999-4923/15/7/1808 #Morpholino

HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. https://www.pnas.org/doi/10.1073/pnas.2221522120 #Morpholino

Non-canonical function of folate/folate receptor 1 during neural tube formation. https://www.biorxiv.org/content/10.1101/2023.07.19.549718v1 #Morpholino and Vivo-#Morpholino

Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1. https://www.cell.com/developmental-cell/pdfExtended/S1534-5807(23)00307-6 #Morpholino

Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium. https://www.nature.com/articles/s41556-023-01187-9 #Morpholino

Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection. https://www.biorxiv.org/content/10.1101/2023.07.12.548523v1 #Morpholino

A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics. https://www.biorxiv.org/content/10.1101/2023.07.11.548539v1 #Morpholino

Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo. https://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(23)00201-1
#Morpholino

Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer. https://link.springer.com/article/10.1007/s13402-023-00839-0 Vivo-#Morpholino

RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa. https://www.nature.com/articles/s41467-023-39606-y #Morpholino

Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms. https://www.pnas.org/doi/10.1073/pnas.2307898120 #Morpholino

Prediction of human pharmacokinetics of phosphorodiamidate #morpholino oligonucleotides in Duchenne muscular dystrophy patients using viltolarsen. https://dmd.aspetjournals.org/content/early/2023/07/19/dmd.123.001425.long

I am headed for the Society for Developmental Biology conference in Chicago. The tooting of #Morpholino citations will take a break for a week.

Development of small fluorescent probes for the analysis of autophagy kinetics. https://www.cell.com/iscience/fulltext/S2589-0042(23)01295-6 #Morpholino