Michele Federico @mich@qoto.org

I've just got to say how happy I am with the Mastodon community, especially all the science/space people that I'm following. This place is the clear winner after the social media meltdown, despite its outstanding issues and missing features.

What makes me even more excited is that it's open and unmonetized, so it's completely immune to shareholder demands or the whim of a billionaire.

Don't worry if your friends aren't here yet, we're your new friends.

"Read the books they're banning. That's where the good stuff is."

--LeVar Burton

Robert Sheckley died on this day 17 years ago. He was a brilliant, witty writer, one of the finest short story writers of Science Fiction, an inspiration to Douglas Adams. His grave is near me and I clean the weeds off when I pass.

There were three men came out of the West
Three kings both great and high
And they have sworn a solemn oath
John Mastodon must die.

They took a tank and ran him down
With bullets in his head
And they have sworn a solemn oath
John Mastodon was dead

But when the Spring came kindly on
And showers began to fall
John Mastodon got up again
And did surprise them all...

Check out my YouTube channel dedicated to promoting science & critical thinking & debunking pseudoscience!

https://www.youtube.com/channel/UCt1bh5OfQV6RHSYU93RTDkw/featured

Reading this recent (2022) article from Fritjof Capra:
The organization of the living:
Maturana’s key insights
included in the latest Constructivist Foundations volume 18(1): 005–011

https://constructivist.info/18/1/005

and I am continually bewildered by the fact that no one in the #Constructivist field figured out yet that #Autopoiesis, although necessary, is not the sufficient condition for #Life.

All #LivingSystems are in fact #DynamicalSystems with memory made of #Material, #Energy, and #Information structures participating continually in both auto- and allopoietic processes.

In fact, the recursive, #Autopoietic processes of learning and growth depend only on (are "structurally coupled" with) the linear #Allopoietic work processes dealing with all the things (resources, waste) in the system's environment and producing the externally observable #behavior of the living (dynamical) system.

The latest update from the COVID-19 Disease Map consortium is now available as a preprint.

In this work, we show how the map can be used for #modelling of #COVID disease mechanisms and #DrugDiscovery. With new winter waves beginning, there is still much to be done in this field.

https://www.biorxiv.org/content/10.1101/2022.12.17.520865v1?med=mas

#SBGN #DiseaseMaps #SystemsBiology #SystemsMedicine