RT @sohailtavazoie
How does Codon bias emerge? @DennisJHsu shows: limiting arginine causes arginine codon switching mutations in cancer: Low Arg aa-> reduced Arg tRNA->ribosome pausing->proteomic shift->DNA evolution. big thx to @s_tavazoie @Columbia @Rockefeller https://www.science.org/doi/10.1126/sciadv.ade9120